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Dasatinib promotes ATRA-induced differentiation of AML cells

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References

  1. Lombardo LJ, Lee FY, Chen P, Norris D, Barrish JC, Behnia K et al. Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem 2004; 47: 6658–6661.

    Article  CAS  Google Scholar 

  2. Wu J, Meng F, Kong LY, Peng Z, Ying Y, Bornmann WG et al. Association between imatinib-resistant BCR–ABL mutation-negative leukemia and persistent activation of LYN kinase. J Natl Cancer Inst 2008; 100: 926–939.

    Article  CAS  Google Scholar 

  3. Vandyke K, Dewar AL, Farrugia AN, Fitter S, To LB, Hughes TP et al. Therapeutic concentrations of dasatinib inhibit in vitro osteoclastogenesis. Leukemia 2009; 23: 994–997.

    Article  CAS  Google Scholar 

  4. Brownlow N, Mol C, Hayford C, Ghaem-Maghami S, Dibb NJ . Dasatinib is a potent inhibitor of tumour-associated macrophages, osteoclasts and the FMS receptor. Leukemia 2009; 23: 590–594.

    Article  CAS  Google Scholar 

  5. Gratacap MP, Martin V, Valera MC, Allart S, Garcia C, Sie P et al. The new tyrosine-kinase inhibitor and anti-cancer drug dasatinib reversibly affects platelet activation in vitro and in vivo. Blood 2009; 114: 1884–1892.

    Article  CAS  Google Scholar 

  6. Schade AE, Schieven GL, Townsend R, Jankowska AM, Susulic V, Zhang R . Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation. Blood 2008; 111: 1366–1377.

    Article  CAS  Google Scholar 

  7. Blake SJ, Bruce Lyons A, Fraser CK, Hayball JD, Hughes TP . Dasatinib suppresses in vitro natural killer cell cytotoxicity. Blood 2008; 111: 4415–4416.

    Article  CAS  Google Scholar 

  8. Miranda MB, Redner RL, Johnson DE . Inhibition of Src family kinases enhances retinoic acid induced gene expression and myeloid differentiation. Mol Cancer Ther 2007; 6: 3081–3090.

    Article  CAS  Google Scholar 

  9. Stegmaier K, Corsello SM, Ross KN, Wong JS, Deangelo DJ, Golub TR . Gefitinib induces myeloid differentiation of acute myeloid leukemia. Blood 2005; 106: 2841–2848.

    Article  CAS  Google Scholar 

  10. Miranda MB, Duan R, Thomas SM, Grandis JR, Redner RL, Jones JE et al. Gefitinib potentiates myeloid cell differentiation by ATRA. Leukemia 2008; 22: 1624–1627.

    Article  CAS  Google Scholar 

  11. Boehrer S, Ades L, Braun T, Galluzzi L, Grosjean J, Fabre C et al. Erlotinib exhibits antineoplastic off-target effects in AML and MDS: a preclinical study. Blood 2008; 111: 2170–2180.

    Article  CAS  Google Scholar 

  12. Chan G, Pilichowska M . Complete remission in a patient with acute myelogenous leukemia treated with erlotinib for non small-cell lung cancer. Blood 2007; 110: 1079–1080.

    Article  CAS  Google Scholar 

  13. Pitini V, Arrigo C, Altavilla G . Erlotinib in a patient with acute myelogenous leukemia and concomitant non-small-cell lung cancer. J Clin Oncol 2008; 26: 3645–3646.

    Article  Google Scholar 

  14. Dos Santos C, Demur C, Bardet V, Prade-Houdellier N, Payrastre B, Recher C . A critical role for Lyn in acute myeloid leukemia. Blood 2008; 111: 2269–2279.

    Article  CAS  Google Scholar 

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Acknowledgements

We thank Bristol-Myers Squibb (New York, NY) for providing dasatinib. This work was supported by National Institutes of Health Grant R01 CA108904.

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Correspondence to D E Johnson.

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Supplementary Information accompanies the paper on the Leukemia website (http://www.nature.com/leu)

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Kropf, P., Wang, L., Zang, Y. et al. Dasatinib promotes ATRA-induced differentiation of AML cells. Leukemia 24, 663–665 (2010). https://doi.org/10.1038/leu.2009.267

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