Abstract
Mutations in SOX9 are associated with male-to-female sex reversal in humans1,2. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating that it can substitute for the sex-determining gene Sry.
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References
Wagner, T. et al. Cell 79, 1111–1120 (1994).
Foster, J.W. et al. Nature 372, 525–530 (1994).
Swain, A. & Lovell Badge, R. Genes Dev. 13, 755–767 (1999).
Morais da Silva, S. et al. Nature Genet. 14, 62–68 (1996).
Kent, J., Wheatley, S.C., Andrews, J.E., Sinclair, A.H. & Koopman, P. Development 122, 2813–2822 (1996).
Bergstrom, D.E., Young, M., Albrecht, K.H. & Eicher, E.M. Genesis. 28, 111–124 (2000).
De Santa Barbara, P. et al. Mol. Cell Biol. 18, 6653–6665 (1998).
Arango, N.A., Lovell-Badge, R. & Behringer, R.R. Cell 99, 409–419 (1999).
Moore, A.W. et al. Mech. Dev. 79, 169–184 (1998).
Scholz, H. et al. J. Biol. Chem. 272, 32836–32846 (1997).
Schedl, A., Montoliu, L., Kelsey, G. & Schutz, G. Nature 362, 258–261 (1993).
Hunt, P.A. et al. Mol. Reprod. Dev. 49, 101–111 (1998).
Bishop, C.E. et al. Nature Genet. 26, 490–494 (2000).
Huang, B., Wang, S., Ning, Y., Lamb, A.N. & Bartley, J. Am. J. Med. Genet. 87, 349–353 (1999).
Pask, A. & Graves, J.A. Cell Mol. Life Sci. 55, 864–875 (1999).
Acknowledgements
We thank U. Ziegler, S. Schmidt, S. Lützkendorf and D. Landrock for excellent technical assistance. This work was supported by the Volkswagen Stiftung and EC-grant QLRT00741.
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Vidal, V., Chaboissier, MC., de Rooij, D. et al. Sox9 induces testis development in XX transgenic mice. Nat Genet 28, 216–217 (2001). https://doi.org/10.1038/90046
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DOI: https://doi.org/10.1038/90046
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