Skip to main content
SpringerLink
Log in

Variations on ligand–receptor complexes

  • News & Views
  • Published:

From Nature Structural Biology

View current issue Submit your manuscript

The complex between BMP-2, a TGF-β family member, and its high affinity receptor provides new insights into the assembly of receptor complexes for members of the cystine-knot growth factor family. A novel proposal for the interaction between Flt3L and its receptor suggests a general scheme for the interaction of closely related receptor tyrosine kinases with structurally diverse ligands, including certain members of the TGF-β family.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: The ‘growth hormone paradigm’.
Figure 2: A novel proposal for receptor engagement of Flt3L2: models of the receptor complexes for Flt3L (left) and VEGF (right).
Figure 3: Three classes of homodimeric cystine-knot growth factors: TGF-β (left), VEGF (middle) and NGF (right).
Figure 4: Similarities and differences in receptor binding by cystine-knot growth factors: receptor complexes of BMP-2 (left), VEGF (middle), and NGF (right).

References

  1. Kirsch, T., Sebald, W., & Dreyer, M.K. Nature Struct. Biol. 7, 492–496 (2000)

    Article  CAS  Google Scholar 

  2. Savvides, S.N., Boone, T. & Karplus, P.A. Nature Struct. Biol. 7, 486–491 (2000)

    Article  CAS  Google Scholar 

  3. Bazan, J.F. Proc. Natl. Acad. Sci. USA 87, 6934–6938 (1990).

    Article  CAS  Google Scholar 

  4. De Vos, A.M., Ultsch, M. & Kossiakoff, A.A. Science 255, 306–312 (1992).

    Article  CAS  Google Scholar 

  5. Rozwarski, D.A. et al. Structure 2, 159–173 (1994).

    Article  CAS  Google Scholar 

  6. Graddis, T.J. et al. J. Biol. Chem. 273, 17626–17633 (1998).

    Article  CAS  Google Scholar 

  7. Sun, P.D. & Davies, D.R. Annu. Rev. Biophys. Biomol. Struct. 24, 269–291 (1995).

    Article  CAS  Google Scholar 

  8. Wiesmann, C. et al. Cell 91, 695–704 (1997).

    Article  CAS  Google Scholar 

  9. Wiesmann, C., Ultsch, M.H., Bass, S.H. & de Vos, A.M. Nature 401, 184–188 (1999).

    Article  CAS  Google Scholar 

  10. Massague, J. Annu. Rev. Biochem. 67, 753–791 (1998).

    Article  CAS  Google Scholar 

  11. Greenwald, J., Fischer, W.H., Vale, W.W. & Choe, S. Nature Struct. Biol. 6, 18–22 (1999).

    Article  CAS  Google Scholar 

  12. Scheufler, C., Sebald, W. & Hulsmeyer, M. J. Mol. Biol. 287, 103–115 (1999).

    Article  CAS  Google Scholar 

  13. Syed, R.S. et al. Nature 395, 511–516 (1998).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank M.K. Dreyer and P.A. Karplus for giving us access to their coordinates, and W. Sebald for sharing data prior to publication.

Author information

Authors and Affiliations

  1. Sunesis Pharmaceuticals, Inc., 3696 Haven Avenue, Suite C, Redwood City, 94063, California, USA

    Christian Wiesmann

  2. the Department of Protein Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, 94080, California, USA

    Abraham M. de Vos

Authors
  1. Christian Wiesmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Abraham M. de Vos
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Abraham M. de Vos.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wiesmann, C., de Vos, A. Variations on ligand–receptor complexes. Nat Struct Mol Biol 7, 440–442 (2000). https://doi.org/10.1038/75825

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/75825

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation