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Cell biology

Stairway to the proteasome

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The study of fast and intricate enzyme reactions requires methods that have the speed and sophistication to match. Such an approach reveals the way in which proteins are tagged with ubiquitin for destruction.

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Figure 1: Models of ubiquitin transfer to a substrate protein that requires degradation.
Figure 2: The stepwise model of ubiquitin (Ub) transfer, validated by Deshaies and colleagues5,6.

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Raman, M., Harper, J. Stairway to the proteasome. Nature 462, 585–586 (2009). https://doi.org/10.1038/462585a

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