Why do cells of the same population respond differently to external death-inducing stimuli? Individuality seems to originate from non-genetic differences in the levels and activation states of proteins.
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References
Spencer, S. L., Gaudet, S., Albeck, J. G., Burke, J. M. & Sorger, P. K. Nature 459, 428–432 (2009).
Ashkenazi, A. Nature Rev. Drug Discov. 7, 1001–1012 (2008).
Newsom-Davis, T., Prieske, S. & Walczak, H. Apoptosis 14, 607–623 (2009).
Albeck, J. G., Burke, J. M., Spencer, S. L., Lauffenburger, D. A. & Sorger, P. K. PLoS Biol. 6, e299 (2008).
Albeck, J. G. et al. Mol. Cell 30, 11–25 (2008).
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Bastiaens, P. When it is time to die. Nature 459, 334–335 (2009). https://doi.org/10.1038/459334a
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DOI: https://doi.org/10.1038/459334a
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