Skip to main content
Log in

Genetics

Paramutable possibilities

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

A curious genetic phenomenon allows certain genetic instructions to be passed between generations without the gene variants involved being transmitted. Some spotty mice provide clues to how this might happen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Model for paramutation at Kit as proposed by Rassoulzadegan et al.1.

References

  1. Rassoulzadegan, M. et al. Nature 441, 469–474 (2006).

    Article  CAS  ADS  PubMed  Google Scholar 

  2. Brink, R. A. Genetics 41, 872–889 (1956).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Chandler, V. L. & Stam, M. Nature Rev. Genet. 5, 532–544 (2004).

    Article  CAS  PubMed  Google Scholar 

  4. Bennett, S. T. et al. Nature Genet. 17, 350–352 (1997).

    Article  CAS  PubMed  Google Scholar 

  5. Rassoulzadegan, M., Magliano, M. & Cuzin, F. Embo J. 21, 440–450 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Herman, H. et al. Nature Genet. 34, 199–202 (2003).

    Article  CAS  PubMed  Google Scholar 

  7. Aufsatz, W., Mette, M. F., van der Winden, J., Matzke, A. J. & Matzke, M. Proc. Natl Acad. Sci. USA 99, 16499–16506 (2002).

    Article  CAS  ADS  PubMed  PubMed Central  Google Scholar 

  8. Hamilton, A., Voinnet, O., Chappell, L. & Baulcombe, D. Embo J. 21, 4671–4679 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Volpe, T. A. et al. Science 297, 1833–1837 (2002).

    Article  CAS  ADS  PubMed  Google Scholar 

  10. Stam, M., Belele, C., Dorweiler, J. E. & Chandler, V. L. Genes Dev. 16, 1906–1918 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Fire, A. et al. Nature 391, 806–811 (1998).

    Article  CAS  ADS  PubMed  Google Scholar 

  12. Lolle, S. J., Victor, J. L., Young, J. M. & Pruitt, R. E. Nature 434, 505–509 (2005).

    Article  CAS  ADS  PubMed  Google Scholar 

  13. Alleman, M. et al. Nature (in the press).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Soloway, P. Paramutable possibilities. Nature 441, 413–414 (2006). https://doi.org/10.1038/441413a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/441413a

  • Springer Nature Limited

This article is cited by

Navigation