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Organic chemistry

Fast reactions ‘on water’

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Efficient reactions in aqueous organic chemistry do not require soluble reactants, as had been thought. A newly developed ‘on-water’ protocol is characterized by short reaction times, and the products are easy to isolate.

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Figure 1: The ‘on water’ protocol, as developed by Sharpless and colleagues2.
Figure 2: Rapid reaction.

References

  1. Daniel, R. M., Finney, J. L. & Stoneham, M. (eds) Phil. Trans. R. Soc. Lond. B 359, 1141–1328 (2004).

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  4. Grieco, P. A. (ed.) Organic Synthesis in Water (Blackie, London, 1998).

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Authors and Affiliations

  1. the Physical Organic Chemistry Unit, Stratingh Institute, University of Groningen, Groningen, 9747 AG, The Netherlands

    Jaap E. Klijn & Jan B. F. N. Engberts

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  1. Jaap E. Klijn
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  2. Jan B. F. N. Engberts
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Klijn, J., Engberts, J. Fast reactions ‘on water’. Nature 435, 746–747 (2005). https://doi.org/10.1038/435746a

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