Abstract
Poor fetal growth is linked with long-term detrimental effects on health in adulthood1. Here we investigate whether the lifespan of male mice is affected by their growth rate when they were suckling and find that limiting growth during that period not only increases longevity but also protects against the life-shortening effect of an obesity-inducing diet later on. By contrast, we find that lifespan is considerably shortened if the postnatal period of growth is accelerated to make up for reduced growth in utero, and that, in addition, these mice are susceptible to the adverse effects on longevity of an obesity-inducing diet after weaning.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Hales, C. N. & Barker, D. J. P. Br. Med. Bull. 60, 5–20 (2001).
Jennings, B. J., Ozanne, S. E., Dorling, M. W. & Hales, C. N. FEBS Lett. 448, 4–8 (1999).
Petry, C. J., Ozanne, S. E., Wang, C. L. & Hales, C. N. Clin. Sci. 93, 147–152 (1997).
Tatar, M., Bartke, A. & Antebi, A. Science 299, 1346–1351 (2003).
Johnson, P. R., Stern, J. S., Horwitz, B. A., Harris, R. E. & Greene, S. F. Am. J. Clin. Nutr. 66, 890–903 (1997).
Wright, W. E. & Shay, J. W. Nature Biotechnol. 20, 682–688 (2002).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Ozanne, S., Hales, C. Catch-up growth and obesity in male mice. Nature 427, 411–412 (2004). https://doi.org/10.1038/427411b
Issue Date:
DOI: https://doi.org/10.1038/427411b
- Springer Nature Limited
This article is cited by
-
Developmental programming of appetite and growth in male rats increases hypothalamic serotonin (5-HT)5A receptor expression and sensitivity
International Journal of Obesity (2020)
-
Type 2 diabetes increases oocyte mtDNA mutations which are eliminated in the offspring by bottleneck effect
Reproductive Biology and Endocrinology (2018)