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Pinning a change on p53

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An enzyme-induced conformational change is now implicated in activating the p53 protein, one of a cell's prime movers in preventing tumour development.

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Figure 1: Regulation of p53 protein by Pin1, as suggested by the results of Zheng et al.1 and Zacchi et al.2.

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Authors and Affiliations

  1. Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK

    Kevin M. Ryan & Karen H. Vousden

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  1. Kevin M. Ryan
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  2. Karen H. Vousden
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Correspondence to Kevin M. Ryan or Karen H. Vousden.

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Ryan, K., Vousden, K. Pinning a change on p53. Nature 419, 795–797 (2002). https://doi.org/10.1038/419795a

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