The use of mathematical modelling to formulate and test theories is still quite rare in biology. It has now been applied to show how a robust, sharp peak of signalling molecules can be formed in developing fruitfly embryos.
References
Gurdon, J. B. & Bourillot, P.-Y Nature 413, 797–803 (2001).
Lander, A. D. et al. Dev. Cell 2, 785–796 (2002).
Eldar, A. et al. Nature 419, 304–308 (2002).
Srinivasan, S. et al. Dev. Cell 2, 91–101 (2002).
Ashe, H. L. & Levine, M. Nature 398, 427–431 (1999).
Decotto, E. & Ferguson, E. L. Development 128, 3831–3841(2001).
Marques, G. et al. Cell 91, 417–426 (1997).
Ross, J. J. et al. Nature 410, 479–483 (2001).
Larraín, J. et al. Development 128, 4439–4447 (2001).
Dale, L. & Wardle, F. C. Semin. Cell Dev. Biol. 10, 319–326 (1999).
Arendt, D. & Nübler-Jung, K. Nature 371, 26 (1994).
St Johnston, D. & Nüsslein-Volhard, C. Cell 68, 201–219 (1992).
Meinhardt, H. BioEssays 24, 185–191 (2002).
Jazwinska, A. et al. Development 126, 3323–3334 (1999).
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Meinhardt, H., Roth, S. Sharp peaks from shallow sources. Nature 419, 261–262 (2002). https://doi.org/10.1038/419261a
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DOI: https://doi.org/10.1038/419261a
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