Abstract
THE availability of dense genetic linkage maps of mammalian genomes makes feasible a wide range of studies, including positional cloning of monogenic traits, genetic dissection of polygenic traits, construction of genome-wide physical maps, rapid marker-assisted construction of congenic strains, and evolutionary comparisons1,2. We have been engaged for the past five years in a concerted effort to produce a dense genetic map of the laboratory mouse3–6. Here we present the final report of this project. The map contains 7,377 genetic markers, consisting of 6,580 highly informative simple sequence length polymorphisms integrated with 797 restriction fragment length polymorphisms in mouse genes. The average spacing between markers is about 0.2 centimorgans or 400 kilobases.
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References
Copeland, N. G. et al. Science 262, 57–66 (1993).
Copeland, N. G. et al. Science 262, 67–82 (1993).
Dietrich, W. F. et al. Genetics 131, 423–447 (1992).
Dietrich, W. F. et al. in Genetic Maps 1992 (ed. O'Brien, S.) 4.110–4.142 (Cold Spring Harbor Laboratory Press, NY, 1992).
Miller, J. C. et al. in Genetic Variants and Strains of the Laboratory Mouse 3rd edn. (eds Lyons, M. F. & Searle, A.) (Oxford Univ. Press, New York, 1994).
Dietrich, W. F. et al. Nature Genet. 7, 220–245 (1994).
Lander, E. S. et al. Genomics 1, 174–181 (1987).
Lincoln, S. E. & Lander, E. S. Genomics 14, 604–610 (1992).
Copeland, N. G. & Jenkins, N. A. Trends Genet. 7, 113 (1991).
Ceci, J. D. et al. Genomics 5, 699–709 (1989).
Buchberg, A. M. et al. Genetics 122, 153–161 (1989).
Jacob, H. J. et al. Nature Genet. 9, 63–69 (1995).
Dib, C. et al. Nature 380, 152–154 (1996).
Larin, Z., Monaco, A. P. & Lehrach, H. Proc. natn. Acad. Sci. U.S.A. 88, 4123 (1991).
Kusumi, K. et al. Mamm. Genome 4, 391–392 (1993).
Hudson, T. et al. Science 270, 1945–1955 (1995).
Rowe, L. B. et al. Mamm. Genome 5, 253–274 (1994).
The European Backcross Collaborative Group. Hum. molec. Genet. 3, 621–627 (1994).
Evans, E. in Genetic Variants and Strains of the Laboratory Mouse 3rd edn (eds Lyons, M. F. & Searle, A.) (Oxford Univ. Press, New York, 1994).
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Dietrich, W., Miller, J., Steen, R. et al. A comprehensive genetic map of the mouse genome. Nature 380, 149–152 (1996). https://doi.org/10.1038/380149a0
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DOI: https://doi.org/10.1038/380149a0
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