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The asexual ploidy cycle and the origin of sex

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Abstract

SEX involves syngamy (gamete fusion), which doubles the amount of DNA in a cell, and meiosis1, which halves it. The result is a 'ploidy cycle' of alternating diploid and haploid phases. Asexual reproduction does not require changes of ploidy, and yet asexual forms may have ploidy cycles. Here I show that such cycles lessen the mutation load, compared with permanent diploidy or poly-ploidy, and are thus likely to evolve in cases where it is always advantageous to have more than one copy of the genome per cell. The asexual ploidy cycle could have facilitated the origin of sex, by providing a means of orderly genetic reduction available im-mediately after the origin of syngamy.

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References

  1. Hurst, L. D. Nature 365, 206–207 (1993).

    Article  ADS  CAS  Google Scholar 

  2. Raikov, I. B. The Protozoan Nucleus (Springer, Berlin, 1982).

    Google Scholar 

  3. Raikov, I. B. in Progress in Protozoology Vol. 3 (eds Patterson D. J. & Corliss J. O.) 21–86 (Biopress, Bristol, 1989).

    Google Scholar 

  4. Haig, D. J. theor. Biol. 163, 15–31 (1993).

    Article  CAS  Google Scholar 

  5. Lewis, W. M. Am. Nat. 125, 692–701 (1985).

    Article  Google Scholar 

  6. Bernstein, C. & Bernstein, H. Aging, Sex, and DNA Repair (Academic, San Diego, 1991).

    Google Scholar 

  7. Cleveland, L. R. Science 105, 287–289, (1947).

    Article  ADS  CAS  Google Scholar 

  8. Margulis, L. & Sagan, D. Origins of Sex (Yale Univ. Press, New Haven, 1986).

    Google Scholar 

  9. Hurst, L. D. & Nurse, P. J. theor. Biol. 150, 561–563 (1991).

    Article  CAS  Google Scholar 

  10. Margulis, L., Corliss, J. O., Melkonian, M. & Chapman, D. J. Handbook of Protoctista (Jones and Bartlett, Boston, 1990).

    Google Scholar 

  11. Kimura, M. & Maruyama, T. Genetics 54, 1337–1351 (1966).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Crow, J. F. in Mathematical Topics in Population Genetics (ed. Kojima, K. I.) 128–177 (Springer, Berlin, 1970).

    Book  Google Scholar 

  13. Kondrashov, A. S. Genet. Res. 40, 325–332 (1982).

    Article  CAS  Google Scholar 

  14. Kondrashov, A. S. Nature 336, 435–440 (1988).

    Article  ADS  CAS  Google Scholar 

  15. Crow, J. F., & Simmons, M. J. in The Genetics and Biology of Drosophila Vol. 3c (eds M. Ashburner, H. L. Carson & J. N. Thompson) 2–35 (Academic, New York, 1983).

    Google Scholar 

  16. Dickson, D. P. E. & Manning, J. T. Heredity 53, 717–720 (1984).

    Article  Google Scholar 

  17. Kirkpatrick, M. & Jenkins, C. D. Nature 339, 300–301 (1989).

    Article  ADS  CAS  Google Scholar 

  18. Charlesworth, B. Genet. Res. 55, 199–221 (1990).

    Article  CAS  Google Scholar 

  19. Drake, J. W. Proc. natn. Acad. Sci. U.S.A. 88, 7160–7164 (1991).

    Article  ADS  CAS  Google Scholar 

  20. Byers, T. J. Int. Rev. Cytol. 99, 311–341 (1986).

    Article  CAS  Google Scholar 

  21. Afon'kin, S. Ju. Arch. Protistenk. 131, 101–112 (1986).

    Article  Google Scholar 

  22. Willumsen, N. B. S., Siemensma, F. & Suhr-Jessen, P. Arch. Protistenk. 134, 303–313 (1987).

    Article  Google Scholar 

  23. Seravin, L. N. & Gudkov, A. V. Zoologicheskij Z. 64, 1090–1093 (1985).

    Google Scholar 

  24. Fan, J.-B., Korman, S. H., Cantor, C. R. & Smith, C. L. Nucleic Acids Res. 19, 1905–1908 (1991).

    Article  CAS  Google Scholar 

  25. Bell, G. Sex and Death in Protozoa (Cambridge Univ. Press, UK, 1988).

    Google Scholar 

  26. Kondrashov, A. S. Genetics 137, 311–318 (1994).

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Knoll, A. H. Science 256, 622–627 (1992).

    Article  ADS  CAS  Google Scholar 

  28. Hasimoto, T. et al. Molec. biol. Evol. 11, 65–71 (1994).

    Google Scholar 

  29. Brugerolle, G. J. Eukaryot. Microbiol. 40, 616–618 (1993).

    Article  Google Scholar 

  30. Muller, D. G. Planta 75, 39–54 (1967).

    Article  CAS  Google Scholar 

  31. Kondrashov, A. S. J. Heredity 84, 372–387 (1993).

    Article  CAS  Google Scholar 

  32. Maguire, M. P. J. theor. Biol. 154, 43–55 (1992).

    Article  CAS  Google Scholar 

  33. Seravin, L. N. & Gudkov, A. V. Tsitologiya 26, 123–131 (1984).

    Google Scholar 

  34. Seravin, L. N. & Gudkov, A. V. Tsitologiya 25, 194–199 (1983).

    Google Scholar 

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  1. Section of Ecology and Systematics, Cornell University, Ithaca, New York, 14853, USA

    Alexey S. Kondrashov

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  1. Alexey S. Kondrashov
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Kondrashov, A. The asexual ploidy cycle and the origin of sex. Nature 370, 213–216 (1994). https://doi.org/10.1038/370213a0

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