Abstract
VISION is dependent on ordered neuronal representations or maps of visual space. These maps depend on precise connections between retinal axons and their targets cells. In mammals, nerve fibres from right and left eyes produce congruent maps of contralateral visual space in adjacent layers of the lateral geniculate nucleus (LGN)1. We have identified an autosomal recessive mutation in Belgian sheepdogs2,3 that eliminates the optic chiasm. In these mutants, all retinal axons project into the ipsilateral optic tract, including those originating in the nasal hemiretina that normally cross midline. These animals exhibit a pronounced horizontal nystagmus4,5. The abnormal ipsilaterally directed nasal fibres innervate the LGN as if they had successfully crossed the midline, terminating in the appropriate layer of the nucleus. As a consequence, the LGN contains non-congruent, mirror-image maps of visual space in adjacent layers. These results show that there is a robust affinity between nasal and temporal retinal axons and specific LGN layers even when all retinal axons originate from a single eye.
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References
Kaas, J. H., Guillery, R. W. & Allman, J. M. Brain Behav. Evol. 6, 253–299 (1972).
Williams, R. W., Garraghty, P. E. & Goldowitz, D. Soc. Neurosci. Abstr. 17, 187 (1991).
Hogan, D., Garraghty, P. E. & Williams, R. W. Soc. Neurosci. Abstr. 19, 524 (1993).
Dell'Osso, L. F. Curr. Neuro. Ophthalmol. 1, 139–172 (1988).
Williams, R. W. & Dell'Osso, L. F. Invest. Ophthalmol. Vis. Sci. 34, 1125 (1993).
Rioch, D. M. J. comp. Neurol. 49, 1–119 (1929).
Sanderson, K. J. J. comp. Neurol. 143, 101–118 (1971).
Apkarian, P., Bour, L. & Barth, P. G. Eur. J. Neurosci. (in the press).
Guillery, R. W. Trends Neurosci. 9, 364–367 (1986).
Stone, J., Campion, J. E. & Leicester, J. J. comp. Neurol. 180, 783–798 (1978).
Cooper, M. L. & Pettigrew, J. D. J. comp. Neurol. 187, 313–348 (1979).
Leventhal, A. G. & Creel, D. J. J. Neurosci. 5, 795–807 (1985).
Balkema, G. W. & Dräger, U. C. Vis. Neurosci. 4, 595–604 (1990).
Hubel, D. H. & Wiesel, T. N. J. Physiol. 218, 33–62 (1971).
Guillery, R. W. & Kaas, J. H. J. comp. Neurol. 143, 73–100 (1971).
Huang, K. & Guillery, R. W. Devl Brain Res. 20, 213–220 (1985).
Guillery, R. W., Lamantia, S. A., Robson, J. A. & Huang, K. J. Neurosci. 5, 1370–1379 (1985).
Rakic, P. Science 214, 928–931 (1981).
Chalupa, L. M. & Williams, R. W. Hum. Neurobiol. 3, 103–107 (1984).
Garraghty, P. E., Shatz, C. J. & Sur, M. Vis. Neurosci. 1, 93–102 (1988).
Berman, N. & Cynader, M. J. Physiol. 224, 363–389 (1972).
Walsh, C., Polley, E. H., Hickey, T. L. & Guillery, R. W. Nature 302, 611–614 (1983).
Sperry, R. W. Proc. natn. Acad. Sci. U.S.A. 50, 703–710 (1963).
Bonhoeffer, F. & Huf, F. Nature 315, 409–410 (1985).
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Williams, R., Hogan, D. & Garraghty, P. Target recognition and visual maps in the thalamus of achiasmatic dogs. Nature 367, 637–639 (1994). https://doi.org/10.1038/367637a0
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DOI: https://doi.org/10.1038/367637a0
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