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Molecular dissection of the secretory pathway

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A combination of biochemistry in animal cell-free systems and genetics in yeast is revealing the molecular machinery of the secretory pathway of eukaryotes. Transporting vesicles have a simple coat structure and employ a general mechanism for fusion that is conserved in evolution.

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Authors and Affiliations

  1. the Program of Cellular Biochemistry and Biophysics, Rockefeller Research Laboratory, Sloan-Kettering Institute, 1275 York Avenue, New York, New York, 10021, USA

    James E. Rothman & Lelio Orci

  2. the Department of Morphology, Institute of Histology and Embryology, University of Geneva Medical School, 1 rue Michel Servet, 1211, Geneva, 4, Switzerland

    James E. Rothman & Lelio Orci

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  1. James E. Rothman
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  2. Lelio Orci
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Rothman, J., Orci, L. Molecular dissection of the secretory pathway. Nature 355, 409–415 (1992). https://doi.org/10.1038/355409a0

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