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Stem cells — hype and hope

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Studies of stem cells will help in understanding the development and function of organs in mammals. They may also offer a way of treating diseases ranging from liver failure to Parkinson's disease.

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Figure 1: Stem-cell transitions.
Figure 2: Dopamine-producing neurons derived from mouse embryonic stem (ES) cells15.
Figure 3: In principle, liver diseases might be treatable by transplanting isolated liver cells (hepatocytes).

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References

  1. Brook, F. A. & Gardner, R. L. Proc. Natl Acad. Sci. USA 94, 5709–5712 (1997).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  2. Thomson, J. A. et al. Science 282, 1145– 1147 (1998).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Shamblott, M. J. et al. Proc. Natl Acad. Sci. USA 95, 13726 –13731 (1998).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  4. Reubinoff, B. E., Pera, M. F., Fong, C.-Y., Trounson, A. & Bongso, A. Nature Biotechnol. 18, 399– 404 (2000).

    Article  CAS  Google Scholar 

  5. Osawa, M., Hanada, K., Hamada, H. & Nakauchi, H. Science 273, 242–245 (1996).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Jackson, K. A., Mi, T. & Goodell, M. A. Proc. Natl Acad. Sci. USA 96, 14482 –14486 (1999).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  7. Gussoni, E. et al. Nature 401, 390–394 (1999).

    ADS  CAS  PubMed  Google Scholar 

  8. Bjornson, C., Rietze, R., Reynolds, B., Magli, M. & Vescovi, A. Science 283, 534– 537 (1999).

    Article  ADS  CAS  PubMed  Google Scholar 

  9. Clarke, D. L. Science 288, 1660–1663 ( 2000).

    Article  ADS  CAS  PubMed  Google Scholar 

  10. Eglitis, M. A. & Mezey, E. Proc. Natl Acad. Sci. USA 94, 4080–4085 ( 1997).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  11. Snyder, E., Taylor, R. & Wolfe, J. Nature 374, 367– 370 (1995).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Olanow, C. W., Kordower, J. H. & Freeman, T. B. Trends Neurosci. 19, 102– 109 (1996).

    Article  CAS  PubMed  Google Scholar 

  13. Studer, L., Tabar, V. & McKay, R. D. Nature Neurosci. 1, 290– 295 (1998).

    Article  CAS  PubMed  Google Scholar 

  14. Brüstle, O. et al. Science 285, 754–756 (1999).

    Article  PubMed  Google Scholar 

  15. Lee, S.-H., Lumelsky, N., Studer, L., Auerbach, J. M. & McKay, R. D. Nature Biotechnol. 18, 675 –679 (2000).

    Article  CAS  Google Scholar 

  16. Kobayashi, N. et al. Science 287, 1258– 1262 (2000).

    Article  ADS  CAS  PubMed  Google Scholar 

  17. Benedetti, S. et al. Nature Med. 6, 447– 450 (2000).

    Article  CAS  PubMed  Google Scholar 

  18. Cameron, H. A. & McKay, R. D. Nature Neurosci. 2, 894–897 ( 1999).

    Article  CAS  PubMed  Google Scholar 

  19. Magavi, S. S., Leavitt, B. R. & Macklis, J. D. Nature 405, 951– 955 (2000).

    Article  ADS  CAS  PubMed  Google Scholar 

  20. Anderson, D. J. Trends Genet. 13, 276–280 (1997).

    Article  CAS  PubMed  Google Scholar 

  21. McKay, R. Science 276, 66–71 ( 1997).

    Article  CAS  PubMed  Google Scholar 

  22. Cory, S. Nature 401, 538–539 ( 1999).

    Article  ADS  CAS  PubMed  Google Scholar 

  23. McCreath, K. J. et al. Nature 405, 1066–1069 (2000).

    Article  ADS  CAS  PubMed  Google Scholar 

  24. Harris, H. The Birth of the Cell (Yale Univ. Press, New Haven, CT, 1999).

    Google Scholar 

  25. Monod, J. Chance and Necessity (Knopf, New York, 1971).

    Google Scholar 

Download references

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Correspondence to Ron McKay.

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McKay, R. Stem cells — hype and hope. Nature 406, 361–364 (2000). https://doi.org/10.1038/35019186

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