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Gli regulation by the opposing activities of Fused and Suppressor of Fused

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Figure 1: Expression profile of vertebrate Fu and regulation of Gli activity.
Figure 2: hFu interacts with hSu(fu) and Gli proteins and regulates nuclear localization of Gli.
Figure 3: hFu promotes nuclear localization of Gli1

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Acknowledgements

We thank V. Dixit and his laboratory staff for various reagents and for advice, P. Polakis, M. Hynes and G. Keller for discussions, and J. Ligos for preparing the figures.

Correspondence and requests for materials should be addressed to F.d.S. The nucleotide sequence of hFu has been deposited at GenBank under accession number AF200815.

Supplementary Information is available on Nature Cell Biology’s World-Wide Web site (http://www.nature.com/ncb) or as paper copy from the London editorial office of Nature Cell Biology.

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Author notes

  1. Maximilien Murone

    Present address: Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, 1066, Epalinges, Switzerland

Authors and Affiliations

  1. Department of Molecular Oncology, Genentech Inc., One DNA Way, South San Francisco, 94080, California, USA

    Maximilien Murone, Shiuh-Ming Luoh & Frederic J. de Sauvage

  2. Department of Molecular Biology, Genentech Inc., One DNA Way, South San Francisco, 94080, California, USA

    Donna Stone, Austin Gurney, Mark Armanini, Christa Grey & Arnon Rosenthal

  3. Department of Pharmacokinetics and Metabolism, Genentech Inc., One DNA Way, South San Francisco, 94080, California, USA

    Wenlu Li

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  1. Maximilien Murone
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Corresponding author

Correspondence to Frederic J. de Sauvage.

Supplementary information

Figure 1

Alignment of the amino-acid sequences of human and Drosophila Fused. (PDF 24 kb)

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Murone, M., Luoh, SM., Stone, D. et al. Gli regulation by the opposing activities of Fused and Suppressor of Fused. Nat Cell Biol 2, 310–312 (2000). https://doi.org/10.1038/35010610

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