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Neurobiology

Inhibitor of neurite outgrowth in humans

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Abstract

Axons are generally believed to be incapable of regeneration in the adult central nervous system1,2. Inhibition results from physical barriers imposed by glial scars, a lack of neurotrophic factors, and growth-inhibitory molecules associated with myelin3,4,5, the insulating axon sheath. These molecules include proteoglycans6, myelin-associated glycoprotein3,5 and, in bovine brain, two proteins called Nogo7,8,9. We have used this bovine sequence to identify the human Nogo gene and have isolated complementary DNA clones encoding three different Nogo isoforms that are potent inhibitors of neurite outgrowth and which may help block the regeneration of the central nervous system in adults.

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Figure 1: Predicted structure of Nogo isoforms and functional activity in vitro.

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Authors and Affiliations

  1. Department of Neuroscience Research, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park (North), Third Avenue, Harlow, Essex, CM19 5AW, UK

    Rabinder Prinjha, Stephen E. Moore, Mary Vinson, Sian Blake, Rachel Morrow, Gary Christie, David L. Simmons & Frank S. Walsh

  2. Departments of Neuroscience Research and Bioinformatics, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park (North), Third Avenue, Harlow, Essex , CM19 5AW, UK

    David Michalovich

Authors
  1. Rabinder Prinjha
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  2. Stephen E. Moore
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  3. Mary Vinson
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  4. Sian Blake
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  5. Rachel Morrow
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  6. Gary Christie
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  7. David Michalovich
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  8. David L. Simmons
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  9. Frank S. Walsh
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Corresponding author

Correspondence to Frank S. Walsh.

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Prinjha, R., Moore, S., Vinson, M. et al. Inhibitor of neurite outgrowth in humans. Nature 403, 383–384 (2000). https://doi.org/10.1038/35000287

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