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The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

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Abstract

The let-23 gene is required for induction of the Caenorhabditis elegans vulva. It is shown that let-23 encodes a putative tyrosine kinase of the epidermal growth factor receptor subfamily. Thus, let-23 might encode the receptor for the inductive signal required for vulval development. Because let-23 acts upstream of let-60 ras in the vulval determination pathway, the identification of the let-23 product provides support for a link in vivo between tyrosine kinase growth factor receptors and ras proteins in a pathway of cell-type determination.

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Authors and Affiliations

  1. Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, California, 91125, USA

    Raffi V. Aroian, Jane E. Mendel & Paul W. Sternberg

  2. Department of Biology, Faculty of Science, Kyushu University, Higashi-ku, Fukuoka, 812, Japan

    Makoto Koga & Yasumi Ohshima

Authors
  1. Raffi V. Aroian
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  2. Makoto Koga
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  3. Jane E. Mendel
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  4. Yasumi Ohshima
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  5. Paul W. Sternberg
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Aroian, R., Koga, M., Mendel, J. et al. The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. Nature 348, 693–699 (1990). https://doi.org/10.1038/348693a0

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