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Presynaptic mechanism for long-term potentiation in the hippocampus

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Abstract

Experiments analysing the statistical properties of synaptic transmission, before and after the induction of long-term potentiation (LTP), suggest that expression of LTP largely arises in a presynaptic mechanism—an increased probability of transmitter release.

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References

  1. Bliss, T. V. P. & Lomo, T. J. Physiol., Lond. 232, 331–356 (1973).

    Article  CAS  Google Scholar 

  2. Bliss, T. V. P. & Lynch, M. in Long-Term Potentiation: From Biophysics to Behavior (eds Landfield, P. W. & Deadwyler, S. A.) 3–72 (Liss, New York, 1988).

    Google Scholar 

  3. Wigstrom, H., Gustafsson, B., Huang, Y.-Y. & Abraham, W. C. Acta physiol. scand. 126, 317–319 (1986).

    Article  CAS  Google Scholar 

  4. Kelso, S. R., Ganong, A. H. & Brown, T. H. Proc. natn. Acad. Sci. U.S.A. 83, 5326–5330 (1986).

    Article  ADS  CAS  Google Scholar 

  5. Malinow, R. & Miller, J. P. Nature 320, 529–530 (1986).

    Article  ADS  CAS  Google Scholar 

  6. Sastry, B. R., Goh, J. W. & Auyeung, A. Science 232, 988–990 (1986).

    Article  ADS  CAS  Google Scholar 

  7. Collingridge, G. L. & Bliss, T. V. P. Trends Neurosci. 10, 288–293 (1987).

    Article  CAS  Google Scholar 

  8. Gustafsson, B. & Wigstrom, H. Trends Neurosci. 11, 156–162 (1988).

    Article  CAS  Google Scholar 

  9. Skrede, K. K. & Malthe-Sorenssen, D. Brain Res. 208, 436–441 (1981).

    Article  CAS  Google Scholar 

  10. Dolphin, A. C., Errington, M. L. & Bliss, T. V. P. Nature 297, 496–498 (1982).

    Article  ADS  CAS  Google Scholar 

  11. Muller, D., Joly, M. & Lynch, G. Science 242, 1694–1697 (1988).

    Article  ADS  CAS  Google Scholar 

  12. Kauer, J. A., Malenka, R. C. & Nicoll, R. A. Neuron 1, 911–917 (1988).

    Article  CAS  Google Scholar 

  13. Davies, S. N., Lester, R. A. J., Reymann, K. G. & Collingridge, G. L. Nature 338, 500–503 (1989).

    Article  ADS  CAS  Google Scholar 

  14. Del Castillo, J. & Katz, B. J. Physiol., Lond. 124, 560–573 (1954).

    Article  CAS  Google Scholar 

  15. Redman, S. J. Physiol. Rev. 70, 165–198 (1990).

    Article  CAS  Google Scholar 

  16. Sayer, R. J., Redman, S. J. & Andersen, P. J. Neurosci. 9, 840–850 (1989).

    Article  CAS  Google Scholar 

  17. Rall, W. & Segev, I. in Voltage and Patch Clamping with Microelectrodes (eds T. G. Smith et al.) 191–215 (American Physiological Society, Bethesda, 1985).

    Book  Google Scholar 

  18. Brown, T. H., Wong, R. K. S. & Prince, D. A. Brain Res. 174, 194–199 (1979).

    Article  Google Scholar 

  19. Yamamoto, C. Expl Brain Res. 46, 170–176 (1982).

    Article  CAS  Google Scholar 

  20. Bekkers, J. M., Richerson, G. B. & Stevens, C. F. Proc. natn. Acad. Sci. U.S.A. 87, 5359–5362 (1990).

    Article  ADS  CAS  Google Scholar 

  21. Bekkers, J. M. & Stevens, C. F. Nature 341, 230–233 (1989).

    Article  ADS  CAS  Google Scholar 

  22. Voronin, L. L. in Synaptic Plasticity in the Hippocampus (eds Haas, H. L. & Buzsaki, G.) 27–30 (Springer, Berlin, 1988).

    Book  Google Scholar 

  23. Foster, T. C. & McNaughton, B. L. Soc. Neurosci. Abstr. 15, 775 (1989).

    Google Scholar 

  24. Horn, R. & Marty, A. J. gen. Physiol. 92, 145–159 (1988).

    Article  CAS  Google Scholar 

  25. Hamill, O. P. et al. Pflugers Arch. 391, 85–100 (1981).

    Article  CAS  Google Scholar 

  26. Forsythe, I. D., Westbrook, G. L. & Mayer, M. L. J. Neurosci. 8, 3733–3741 (1988).

    Article  CAS  Google Scholar 

  27. Edwards, F. A., Konnerth, A., Sakmann, B. & Takahashi, T. Pflugers Arch. 414, 600–612 (1989).

    Article  CAS  Google Scholar 

  28. Blanton, M. G., Lo Turco, J. J. & Kriegstein, A. R. J. Neurosci. Meth. 30, 203–210 (1989).

    Article  CAS  Google Scholar 

  29. Bekkers, J. M. & Stevens, C. F. Progr. Brain Res. 83, 37–45 (Elsevier, Amsterdam, 1990).

    Google Scholar 

  30. Piomelli, D. et al. Nature 328, 38–43 (1987).

    Article  ADS  CAS  Google Scholar 

  31. Williams, J. H., Errington, M. L., Lynch, M. A. & Bliss, T. V. P. Nature 341, 739–742 (1989).

    Article  ADS  CAS  Google Scholar 

  32. Manilow, R. & Tsien, R. W. Nature 346, 177–180 (1990).

    Article  ADS  Google Scholar 

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Authors and Affiliations

  1. The Salk Institute, Howard Hughes Medical Institute, 10010 North Torrey Pines Road, La Jolla, California, 92037, USA

    John M. Bekkers & Charles F. Stevens

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  1. John M. Bekkers
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  2. Charles F. Stevens
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Bekkers, J., Stevens, C. Presynaptic mechanism for long-term potentiation in the hippocampus. Nature 346, 724–729 (1990). https://doi.org/10.1038/346724a0

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