Abstract
Mutagenesis of the fos protein supports the hypothesis that a heptad repeat of leucine residues stabilizes the interaction between the fos and jun proteins. We show that the complex between fos and jun can bind to DNA more tightly than either protein alone and that basic residues adjacent to the leucine repeat offos contribute to the DNA-binding potential of the complex.
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Rauscher III, F. J. et al. Science 240, 1010–1016 (1988).
Chiu, R. et al. Cell 54, 541–552 (1988).
Sassone-Corsi, P., Lamph, W. W., Kamps, M. & Verma, I. M. Cell 54, 553–560 (1988).
Vogt, P. K., Bos, T. J. & Doolittle, R. F. Proc. natn. Acad. Sci. U.S.A. 84, 3316–3319 (1987).
Landschulz, W. H., Johnson, P. F. & McKnight, S. L. Science 240, 1759–1764 (1988).
Hope, I. A. & Struhl, K. Cell 46, 885–894 (1986).
Bohmann, D. et al. Science 238, 1386–1392 (1987).
Rauscher III, F. J., Sambucetti, L. C., Curran, T., Distel, R. J. & Spiegelman, B. M. Cell 52, 471–480 (1988).
Ho, Y-S., Wulff, D. L. & Rosenberg, M. Genes Dev. 2, 184–195 (1988).
Davis, R. L., Weintraub, H. & Lassar, A. B. Cell 51, 987–1000 (1987).
Villares, R. & Cabrera, C. V. Cell 50, 415–424 (1987).
Ryder, K., Lau, L. F. & Nathans, D. Proc. natn. Acad. Sci. U.S.A. 85, 1487–1491 (1988).
Hinnebusch, A. G. Proc. natn. Acad. Sci. U.S.A. 81, 6442–6446 (1984).
Van Straaten, F., Muller, R., Curran, T., van Beveren, C. & Verma, I. M. Proc. natn. Acad. Sci. U.S.A. 80, 3183–3187 (1983).
Cohen, D. R. & Curran, T. Molec. cell Biol. 8, 2063–2069 (1988).
Watson, D. K., Psallidopoulos, M. C., Samuel, K. P., Dalla-Favera, R. & Papas, T. S. Proc. natn. Acad. Sci. U.S.A. 80, 3642–3645 (1983).
Stanton, L. W., Schwab, M. & Bishop, J. M. Proc. natn. Acad. Sci. U.S.A. 83, 1772–1776 (1986).
Leogouy, E. et al. EMBO J. 6, 3359–3366 (1987).
Schwarz, E., Scherer, G., Hobom, G. & Kossel, H. Nature 272, 410–414 (1978).
Kunkel, T. A. Proc. natn. Acad. Sci. U.S.A. 82, 488–492 (1985).
Curran, T., Gordon, M. B., Rubino, K. L. & Sambucetti, L. C. Oncogene 2, 80–84 (1987).
Hann, S. R., King, M. W., Bentley, D. L., Anderson, C. W. & Eisenmann, R. N. Cell 52, 185–195 (1988).
Melton, D. A. et al. Nucleic Acids Res. 18, 7035–7056 (1984).
Vosatka, R. J., Hermanowski-Vosatka, A., Metz, R. & Ziff, E. B. J. Cell. Physiol. (in the press).
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Kouzarides, T., Ziff, E. The role of the leucine zipper in the fos–jun interaction. Nature 336, 646–651 (1988). https://doi.org/10.1038/336646a0
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DOI: https://doi.org/10.1038/336646a0
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