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The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens

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Abstract

T cells with Vβ3+αβ receptors are deleted by self-tolerance in mice with particular major histocompatibility complex/self-antigen combinations. This also occurs for other Vβ elements. Polymorphisms in the major histocompatibility complex and / or the self-antigens that cause massive deletion of T cells using particular Vβ elements may be maintained by the need to balance the advantage of a diverse T-cell repertoire against the potential involvement of those elements in autoimmune disease.

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References

  1. Marrack, P. & Kappler, J. Science 238, 1073–1079 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Babbitt, B., Allen, P., Matsueda, G., Haber, E. & Unanue, E. Nature 317, 359–361 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Buus, S., Sette, A., Colon, S., Miles, C. & Grey, H. Science 235, 1353–1358 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Bjorkman, P. J. et al. Nature 329, 506–512 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Bjorkman, P. J. et al. Nature 329, 512–518 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Ajitkumar, P. et al. Cell (in the press).

  7. Roehm, N. et al. Cell 38, 577–584 (1984).

    Article  CAS  PubMed  Google Scholar 

  8. Kappler, J., Roehm, N. & Marrack, P. Cell 49, 273–280 (1987).

    Article  CAS  PubMed  Google Scholar 

  9. Snodgrass, R., Dembic, Z., Steinmetz, M. & von Boehmer, H. Nature 315, 232–233 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  10. Arden, B., Klotz, J., Siu, G. & Hood, L. Nature 316, 783–787 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  11. Bevan, M. & Fink, P. Immunol. Rev. 42, 3–19 (1978).

    Article  CAS  PubMed  Google Scholar 

  12. Zinkernagel, R. M. et al. J. exp. Med. 147, 882–896 (1976).

    Article  Google Scholar 

  13. Kappler, J., Staerz, U., White, J. & Marrack, P. Nature 332, 35–40 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

  14. MacDonald, H. R. et al. Nature 332, 40–44 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

  15. Lo, D., Ron, Y. & Sprent, J. Surv. Immun. Res. 5, 221–232 (1986).

    Article  CAS  Google Scholar 

  16. Sprent, J. J. exp. Med. 147, 1159–1174 (1978).

    Article  CAS  PubMed  Google Scholar 

  17. Marrack, P. & Kappler, J. Nature 332, 840–842 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

  18. Bill, J., Apple, V. & Palmer, E. Proc. natn. Acad. Sci. U.S.A. (in the press).

  19. Hedrick, S., Cohen, D., Nielson, E. & Davis, M. M. Nature 308, 149–153 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  20. Samelson, L., Germain, R. & Schwartz, R. Proc. natn. Acad. Sci. U.S.A. 80, 6972–6976 (1983).

    Article  ADS  CAS  Google Scholar 

  21. Festenstein, H. Transplantn. Rev. 15, 62–88 (1973).

    CAS  Google Scholar 

  22. Katz, M. E. & Janeway, C. A. J. Immun. 134, 2064–2070 (1985).

    CAS  PubMed  Google Scholar 

  23. Festenstein, H., Bishop, C. & Taylor, B. A. Immunogenetics 5, 357–361 (1977).

    Article  Google Scholar 

  24. Click, R. et al. J. Immun. 139, 321–325 (1987).

    CAS  PubMed  Google Scholar 

  25. Abe, R., Ryan, J. J. & Hodes, R. J. J. exp. Med. 165, 1113–1129 (1987).

    Article  CAS  PubMed  Google Scholar 

  26. Abromson-Leeman, S. R., Laning, J. C. & Dorf, M. E. J. Immun. 140, 1726–1731 (1988).

    CAS  PubMed  Google Scholar 

  27. Janeway, C. A., Jr., Fischer-Lindahl, K. & Hammerling, U. Immun. Today 9, 125–126 (1988).

    Article  PubMed  Google Scholar 

  28. Kappler, J. et al. Cell 49, 263–271 (1987).

    Article  CAS  PubMed  Google Scholar 

  29. Webb, S. R. & Sprent, J. Int. Rev. Immun. 1, 151–182 (1986).

    Article  Google Scholar 

  30. Matzinger, P. & Bevan, M. J. Cell. Immun. 33, 92–100 (1977).

    Article  CAS  Google Scholar 

  31. Korngold, R. & Sprent, J. J. exp. Med. 151, 314–327 (1980).

    Article  CAS  PubMed  Google Scholar 

  32. De Kruyfi, R. H., Ju, S.-T., Laning, J., Cantor, H. & Dorf, M. E. J. Immun. 137, 1109–1114 (1986).

    Google Scholar 

  33. Lynch, D. H., Gress, R. E., Needleman, B. W., Rosenberg, S. A. & Hodes, R. J. J. Immun. 134, 2071–2078 (1985).

    CAS  PubMed  Google Scholar 

  34. Van Ewijk, W. et al. Cell 53, 357–370 (1988).

    Article  CAS  PubMed  Google Scholar 

  35. Behlke, M., Chou, H., Huppi, K. & Loh, D. Proc. natn. Acad. Sci. U.S.A. 83, 767–771 (1986).

    Article  ADS  CAS  Google Scholar 

  36. Garman, R., Ko, J.-L., Vulpe, C. & Raulet, D. Proc. natn. Acad. Sci., U.S.A. 83, 3987–3991 (1986).

    Article  ADS  CAS  Google Scholar 

  37. Fink, P. J. et al. Nature 321, 219–226 (1986).

    Article  ADS  CAS  PubMed  Google Scholar 

  38. Barth, R. et al. Nature 316, 517–523 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  39. Wade, T., Bill, J., Marrack, P., Palmer, P. C. & Kappler, J. J. Immun. (in the press).

  40. Kotzin, B., Barr, V. & Palmer, E. Science 229, 167–171 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  41. Acha-Orbea, H. et al. Cell 54, 263–273 (1988).

    Article  CAS  PubMed  Google Scholar 

  42. Todd, J. A. et al. Science 240, 1003–1009 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

  43. Julius, M., Simpson, E. & Herzenberg, L. Eur. J. Immun. 3, 645–649 (1973).

    Article  CAS  Google Scholar 

  44. Leo, O., Foo, M., Sachs, D. H., Samelson, L. E. & Bluestone, L. Proc. natn. Acad. Sci., U.S.A. 84, 1374–1378 (1987).

    Article  ADS  CAS  Google Scholar 

  45. Kappler, J., Skidmore, B., White, J. & Marrack, P. J. exp. Med. 153, 1198–1214 (1981).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Kappler, J. & Marrack, P. J. exp. Med. 148, 1510–1522 (1978).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Howard Hughes Medical Institute and Division of Basic Immunology, Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson Street, Denver, Colorado, 80206, USA

    Ann M. Pullen, Philippa Marrack & John W. Kappler

  2. Departments of Biochemistry, Biophysics and Genetics, University of Colorado Health Sciences Center, Denver, Colorado, 80206, USA

    Philippa Marrack

  3. Departments of Microbiology, Immunology and Medicine, University of Colorado Health Sciences Center, Denver, Colorado, 80206, USA

    Philippa Marrack & John W. Kappler

Authors
  1. Ann M. Pullen
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  2. Philippa Marrack
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  3. John W. Kappler
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Pullen, A., Marrack, P. & Kappler, J. The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens. Nature 335, 796–801 (1988). https://doi.org/10.1038/335796a0

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  • DOI: https://doi.org/10.1038/335796a0

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