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The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice

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Abstract

When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region is introduced into the germline of mice, skin lesions are induced that resemble Kaposi's sarcoma seen in AIDS. Our findings indicate that HIV could play a direct part in causing cancer.

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Author notes

  1. Jonathan Vogel, Steven H. Hinrichs, R. Kay Reynolds & Gilbert Jay

    Present address: Laboratory of Virology, American Red Cross, 15601 Crabbs Branch Way, Rockville, Maryland, 20855, USA

Authors and Affiliations

  1. Laboratory of Molecular Virology, National Cancer Institute, Bethesda, Maryland, 20892, USA

    Jonathan Vogel, Steven H. Hinrichs, R. Kay Reynolds & Gilbert Jay

  2. Department of Human Pathology, University of California, Davis, California, 95616, USA

    Steven H. Hinrichs & Paul A. Luciw

Authors
  1. Jonathan Vogel
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  2. Steven H. Hinrichs
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  3. R. Kay Reynolds
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  4. Paul A. Luciw
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  5. Gilbert Jay
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Vogel, J., Hinrichs, S., Reynolds, R. et al. The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice. Nature 335, 606–611 (1988). https://doi.org/10.1038/335606a0

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