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T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

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Abstract

T lymphocytes reactive with the product of the Mlsa-allele of the minor lymphocyte stimulating (Mls) locus use a predominant T-cell receptor β-chain variable gene segment (Vβ6). Such Vβ6-bearing T cells are selectively eliminated in the thymus of Mlsa-bearing mice, consistent with a model in which tolerance to self antigens is achieved by clonal deletion.

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Authors and Affiliations

  1. Ludwig Institute for Cancer Research, Lausanne Branch, 1066, Epalinges, Switzerland

    H. Robson MacDonald, Rosemary K. Lees & Rawleigh C. Howe

  2. Institute of Pathology, University Hospital, 8091, Zurich, Switzerland

    Reto Schneider, Hans Acha-Orbea, Rolf M. Zinkernagel & Hans Hengartner

  3. Department of Immunology, London Hospital Medical College, London, UK

    Hilliard Festenstein

Authors
  1. H. Robson MacDonald
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  2. Reto Schneider
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  3. Rosemary K. Lees
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  4. Rawleigh C. Howe
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  5. Hans Acha-Orbea
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  6. Hilliard Festenstein
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  7. Rolf M. Zinkernagel
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  8. Hans Hengartner
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MacDonald, H., Schneider, R., Lees, R. et al. T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens. Nature 332, 40–45 (1988). https://doi.org/10.1038/332040a0

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  • DOI: https://doi.org/10.1038/332040a0

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