The complementary DNA sequence encoding the Mr 28,000 antigen of Schistosoma mansoni has been isolated and expressed in Escherichia coli. Experimental vaccination of rats, hamsters and monkeys with a recombinant fusion protein induces a strongly cytotoxic antibody response. Immunization of rats and hamsters with this protein leads to significant protection against a natural challenge infection with live cercariae.
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Balloul, J., Sondermeyer, P., Dreyer, D. et al. Molecular cloning of a protective antigen of schistosomes. Nature 326, 149–153 (1987). https://doi.org/10.1038/326149a0
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DOI: https://doi.org/10.1038/326149a0
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