Abstract
Interleukin-1 (IL-1) is a factor that can induce proliferation of murine T lymphocytes1,2 and can elicit a variety of other biological responses. These include bone resorption3, fibroblast proliferation4, acute phase protein release from hepatocytes5, cartilage breakdown6 and fever7. This spectrum of activities is consistent with a role for IL-1 as a mediator of inflammation. Recently, sequence data have shown that there are at least two members of the IL-1 family; these distantly related proteins have been termed IL-1α and IL-1β8–11. We have found previously that both murine T cells and fibroblasts possess a relative molecular mass (Mr) ∼80,000 (80K) plasma membrane receptor for human IL-1β12,13. We show here that the receptor for IL-1α on both murine and human cells is identical to that for IL-1β. This result raises the issue of what separation, if any, there might be between the biological activities of IL-1α and IL-1β.
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References
Gery, I. & Waksman, B. H. J. exp. Med. 136, 143–155 (1972).
Gillis, S. & Mizel, S. B. Proc. natn. Acad. Sci. U.S.A. 78, 1133–1137 (1981).
Dewhirst, F. E., Stashenko, P. P., Mole, J. E. & Tsurumachi, T. J. Immun. 135, 2562–2568 (1985).
Schmidt, J. A., Mizel, S. B., Cohen, D. & Green, I. J. Immunology 118, 2177–2182 (1982).
Dinarello, C. A. Rev. infect. Dis. 6, 51–95 (1984).
Sakatvala, J., Sarsfield, S. J. & Townsend, Y. J. exp. Med. 162, 1208–1227 (1985).
Dinarello, C. A., Goldin, N. P. & Wolff, S. M. J. exp. Med. 139, 1369–1381 (1974).
March, C. J. et al. Nature 315, 641–646 (1985).
Auron, P. E. et al. Proc. natn. Acad. Sci. U.S.A. 81, 7907–7911 (1984).
Lomedico, P. T. et al. Nature 312, 458–462 (1984).
Furutani, Y. et al. Nucleic Acids Res. 13, 5869–5882 (1985).
Dower, S. K. et al. J. exp. Med. 162, 501–515 (1985).
Dower, S. K., Call, S., Gillis, S. & Urdal, D. L. Proc. natn. Acad. Sci. U.S.A. 83, 1060–1065 (1986).
Giri, J. G., Lomedico, P. T. & Mizel, S. B. J. Immun. 134, 343–349 (1985).
Kronheim, S. R. et al. J. exp. Med. 161, 490–502 (1985).
Schmidt, J. A. J. exp. Med. 160, 772–787 (1984).
Segal, D. M. & Hurwitz, E. J. Immun. 118, 1338–1347 (1977).
Conlon, P. J. J. Immun. 131, 1280–1282 (1983).
Cuatrecasas, P. & Hollenberg, M. D. Adv. Protein Chem. 30, 251–451 (1975).
Aggarwal, B. B., Eessalau, T. E. & Haas, P. E. Nature 318, 665–667 (1985).
Betsholz, C. et al. Nature 320, 695–699 (1986).
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Dower, S., Kronheim, S., Hopp, T. et al. The cell surface receptors for interleukin-1α and interleukin-1β are identical. Nature 324, 266–268 (1986). https://doi.org/10.1038/324266a0
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DOI: https://doi.org/10.1038/324266a0
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