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X-linkage of steroid sulphatase in the mouse is evidence for a functional Y-linked allele

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A Corrigendum to this article was published on 01 August 1985

Abstract

In the human there is an X-linked gene affecting steroid sulphatase (STS) activity which, when deficient, is associated with X-linked congenital ichthyosis1,2. The gene (STS) is located on the distal tip of the short arm3–6 and is only partially inactivated when it is on the inactive X-chromosome7–10. In the mouse, the genetics of STS are not clear; the results of one study using XX:X0 oocyte comparisons indicated X-linkage11, but three other studies using STS variants have produced segregation data compatible with autosomal linkage of murine STS12–14. Here we present the results of STS assays of crosses of deficient C3H/An male mice12 to normal X0 animals which demonstrate X-linkage of STS in the mouse and indirectly indicate the existence of a functional STS allele on the Y-chromosome which undergoes obligatory recombination during meiosis with the X-linked allele.

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Author notes

  1. Marcello Siniscalco: Memorial Sloan-Kettering Cancer Center and Department of Cell Biology and Genetics, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, New York 10021, USA

Authors and Affiliations

  1. The Center for Inherited Diseases, Departments of Medicine and Genetics, SK-50, University of Washington, Seattle, Washington, 98195, USA

    Elisabeth Keitges, Martha Rivest, Marcello Siniscalco & Stanley M. Gartler

Authors
  1. Elisabeth Keitges
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  2. Martha Rivest
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  3. Marcello Siniscalco
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  4. Stanley M. Gartler
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Keitges, E., Rivest, M., Siniscalco, M. et al. X-linkage of steroid sulphatase in the mouse is evidence for a functional Y-linked allele. Nature 315, 226–227 (1985). https://doi.org/10.1038/315226a0

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