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X-linked steroid sulfatase: Evidence for different gene-dosage in males and females

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Summary

Steroid sulfatase (STS) activities in female fibroblast strains are significantly higher than in male strains, as determined by cleavage of dehydroepiandrosterone sulfate. The difference is probably not due to hormonal control of gene expression, but suggests that for this X-linked locus there is no gene dosage compensation.

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References

  • Bøyum, A.: Isolation of lymphocytes, granulocytes and macrophages. Scand. J. Immunol. 5 [Suppl. 5], 9–15 (1976)

    Google Scholar 

  • Campana, T., Szabo, P., Piomelli, S., Siniscalco, M.: The Xga antigen on red cells and fibroblasts. Cytogenet. Cell Genet. 22, 524–526 (1978)

    Google Scholar 

  • Dofuku, R., Tettenborn, U., Ohno, S.: Testosterone “regulon” in the mouse kidney. Nature New Biol. 232, 5–7 (1971)

    Google Scholar 

  • Dolaney, J. T., Moser, H. W.: In: The metabolic basis of inherited disease, Stanbury, J. B., Wyngaarden, J. R., Frederickson, D. S. (eds.), pp. 770–809. New York: McGraw-Hill 1978

    Google Scholar 

  • France, J. T.: Steroid sulfatase deficiency. Paper presented at the Fifth International Congress on Hormonal Steroids, New Delhi, 1978

  • Gillman, S. M., Tson, K. C., Seligman, A. M.: The colorimetric estimation of α-d-galactosidase activity and some comparisons with β-d-galactosidase. Arch. Biochem. Biophys. 98, 229–234 (1960)

    Google Scholar 

  • Hameister, H., Wolff, G., Lauritzen, C. H., Lehmann, W. O., Hauser, A., Ropers, H. H.: Clinical and biochemical investigations on patients with partial deficiency of placental steroid sulfatase. Hum. Genet. 46, 199–207 (1979)

    Google Scholar 

  • Krone, W., Wolf, U.: Chromosome variation and gene action. Hereditas 86, 31–36 (1977)

    Google Scholar 

  • Kubilus, J., Tarascio, A. J., Baden, H. P.: Steroid-sulfatase deficiency in sex-linked ichthyosis. Am. J. Hum. Genet. 31, 50–53 (1979)

    Google Scholar 

  • Lyon, M. F.: Gene action in the X-chromosome of the mouse (Mus musculus L.). Nature 190, 372–374 (1961)

    Google Scholar 

  • Mohandas, T., Shapiro, L J., Sparkes, R. S., Sparkes, M. C.: Regional assignment of the steroid sulfatase-X-linked ichthyosis locus: Implications for a non-inactivated region on the short arm of the human X-chromosome. Proc. Natl. Acad. Sci. USA 76, 5779–5783 (1979)

    Google Scholar 

  • Müller, C. R., Westerveld, A., Migl, B., Franke, W., Ropers, H. H.: Regional assignment of the gene locus for steroid sulfatase. Hum. Genet. 54, 201–204 (1980)

    Google Scholar 

  • Race, R. R., Sanger, R.: Blood groups in man, 6th ed., pp. 578–593 and 594–618. Oxford: Blackwell Scientific 1975

    Google Scholar 

  • Shapiro, L. J., Weiss, R., Webster, D., France, J. T.: X-linked ichthyosis due to steroid sulfatase deficiency. Lancet 1978 I, 70–72 (1978a)

    Google Scholar 

  • Shapiro, L. J., Weiss, R., Buxman, M. M., Vidgoff, J., Dimond, R. L., Enzymatic basis of X-linked ichthyosis. Lancet 1978 II, 756–757

    Google Scholar 

  • Shapiro, L. J., Mohandas, T., Weiss, R., Romeo, G.: Noninactivation of an X-chromosome locus in man. Science 204, 1224–1226 (1979)

    Google Scholar 

  • Steele, M. W., Migeon, B. R.: Sex differences in activity of glucose-6-phosphate dehydrogenase from cultured human fetal lung cells despite X-inactivation. Biochem. Genet. 9, 163–168 (1973)

    Google Scholar 

  • Wilcoxon, F., Katti, S. K., Wilcox, R. A.: Critical values and probability levels for the Wilcoxon Rank Sum Test and the Wilcoxon Signed Rank Test. Peal River, NY: Lederle Laboratories (Division of the American Cyanamid Co.) 1963

    Google Scholar 

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Müller, C.R., Migl, B., Traupe, H. et al. X-linked steroid sulfatase: Evidence for different gene-dosage in males and females. Hum Genet 54, 197–199 (1980). https://doi.org/10.1007/BF00278971

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  • DOI: https://doi.org/10.1007/BF00278971

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