Abstract
Retroviral oncogenes (v-onc) are derived from cellular genes (c-onc) which are highly conserved among different species1–3. Retrovirus-transduced oncogenes are most commonly associated with the induction of haematopoietic tumours and sarcomas4. The avian retrovirus Mill Hill no. 2 (MH2) was isolated from a spontaneous ovarian tumour of a chicken and is distinguished by the predominant induction of liver and kidney carcinomas in fowl4–6. MH2 also induces transformation of fibroblasts, macrophages and epithelial cells in culture2,6,7. The genome of MH2 contains two unrelated and independently expressed cell-derived oncogenes, v-mil and v-myc8,9. Three other viral isolates among avian acute transforming retroviruses contain the v-myc oncogene2,10, but only MH2 contains both v-myc and v-mil. Hence, some of the pathogenic specificities of MH2 may be due to the simultaneous expression of two oncogenes. The murine sarcoma virus 3611 (3611-MSV) isolated from a mouse carrying lung carcinoma and peritoneal tumours11, induces fibrosarcomas in newborn mice and the transformation of fibro blasts and epithelial cells in culture11,12. The oncogenic properties of 3611-MSV are due to the presence in its genome of a cell-derived oncogene termed v-raf13. We report here that the two independently transduced oncogenes v-mil and v-raf are closely related and that they were apparently derived from homologous cellular genes of avian and mammalian species.
Similar content being viewed by others
References
Bishop, J. M. A. Rev. Biochem. 52, 301–354 (1983).
Bister, K. in Mechanisms of Viral Leukaemogenesis (eds Goldman, J. M. & Jarrett, J. O.) 38–63 (Churchill-Livingstone, Edinburgh, 1984).
Weinberg, R. A. Cell 30, 3–4 (1982).
Beard, J. W. in Viral Oncology (ed. Klein, G.) 55–87 (Raven, New York, 1980).
Carr, J. G. Br. J. Cancer 14, 77–82 (1960).
Alexander, R. W., Moscovici, C. & Vogt, P. K. J. natn. Cancer Inst. 62, 359–366 (1979).
Graf, T. & Beug, H. Biochim. biophys. Acta 516, 269–299 (1978).
Jansen, H. W., Patschinsky, T. & Bister, K. J. Virol. 48, 61–73 (1983).
Jansen, H. W., Rückert, B., Lurz, R. & Bister, K. EMBO J. 2, 1969–1975 (1983).
Bister, K. & Duesberg, P. H. Cold Spring Harb. Symp. quant. Biol. 44, 801–822 (1980).
Rapp, U. R., Reynolds, F. H. & Stephenson, J. R. J. Virol. 45, 914–924 (1983).
Keski-Oja, J., Rapp, U. R. & Vaheri, A. J. cell. Biochem. 20, 139–148 (1982).
Rapp, U. R. et al. Proc. natn. Acad. Sci. U.S.A. 80, 4218–4222 (1983).
Bonner, T. I. et al. Science (in the press).
Shibuya, M. & Hanafusa, H. Cell 30, 787–795 (1982).
Besmer, P., Snyder, H. W., Murphy, J. E., Hardy, W. D. & Parodi, A. J. Virol. 46, 606–613 (1983).
Besmer, P. et al. Nature 303, 825–828 (1983).
Whang-Peng, J. et al. Science 215, 181–182 (1982).
Pathak, S., Strong, L. C., Ferrell, R. E. & Trindade, A. Science 217, 939–941 (1982).
Cohen, A. J. et al. New Engl. J. Med. 301, 592–594 (1979).
Mark, J., Dahlenfors, R., Ekedahl, C. & Stenman, G. Cancer Genet. Cytogenet. 2, 231–241 (1980).
Klein, G. Cell 32, 311–315 (1983).
Frykberg, L. et al. Cell 32, 227–238 (1983).
Land, H., Parada, L. F. & Weinberg, R. A. Nature 304, 596–602 (1983).
Ruley, H. E. Nature 304, 602–606 (1983).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jansen, H., Lurz, R., Bister, K. et al. Homologous cell-derived oncogenes in avian carcinoma virus MH2 and murine sarcoma virus 3611. Nature 307, 281–284 (1984). https://doi.org/10.1038/307281a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/307281a0
- Springer Nature Limited
This article is cited by
-
The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy
Journal of Hematology & Oncology (2020)
-
Regulation of RAF protein kinases in ERK signalling
Nature Reviews Molecular Cell Biology (2015)
-
Targeting BRAF mutant metastatic colorectal cancer: clinical implications and emerging therapeutic strategies
Targeted Oncology (2015)
-
Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond
Nature Reviews Cancer (2014)
-
Retroviral oncogenes: a historical primer
Nature Reviews Cancer (2012)