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A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells

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Abstract

The cellular oncogene c-Ki-ras is amplified 30- to 60-fold in cells of the mouse adrenocortical tumour Y1. The amplified oncogene is located in double minute chromosomes and in a homogeneously staining chromosomal region, common karyotypical anomalies of tumour cells. The amounts of c-Ki-ras specific mRNA and of the protein (p21) encoded by the amplified gene are correspondingly elevated. Amplification and enhanced expression of cellular oncogenes may contribute to the genesis and/or maintenance of at least some naturally occurring tumours.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, University of California Medical Center, San Francisco, California, 94143, USA

    Manfred Schwab, Kari Alitalo, Harold E. Varmus & J. Michael Bishop

  2. Department of Human Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA

    Donna George

Authors
  1. Manfred Schwab
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  2. Kari Alitalo
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  3. Harold E. Varmus
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  4. J. Michael Bishop
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  5. Donna George
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Schwab, M., Alitalo, K., Varmus, H. et al. A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells. Nature 303, 497–501 (1983). https://doi.org/10.1038/303497a0

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