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Genetic evidence that a Y-linked gene in man is homologous to a gene on the X chromosome

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Abstract

The mammalian sex chromosomes are thought to be related to each other by sharing a common origin. That is, the X and Y chromosomes originally evolved from a pair of chromosomes that only differed at the locus determining sexual differentiation1,2. For example, this evolutionary relationship is reflected during meiosis3 in chromosomal pairing between the tip of the human X chromosome short arm and the Y chromosome which presumably implies sequence homology4. However, compelling genetic evidence for functional homology between the mammalian X and Y chromosome is lacking. We describe here the localization of a gene to the tip of the short arm of the human X chromosome and evidence for a related gene on the Y chromosome.

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References

  1. Ohno, S. A. Rev. Genet. 3, 495–524 (1969).

    Article  Google Scholar 

  2. Ferguson-Smith, M. A. J. med. Genet. 2, 145–155 (1965).

    Article  Google Scholar 

  3. Pearson, P. C. & Bobrow, M. Nature 226, 959–961 (1970).

    Article  ADS  CAS  Google Scholar 

  4. Rasmussen, S. W. & Holm, P. B. Hereditas 93, 187–126 (1980).

    Google Scholar 

  5. Levy, R., Dilley, J., Fox, R. I. & Warnke, R. Proc. natn. Acad. Sci. U.S.A. 76, 6552–6556 (1979).

    Article  ADS  CAS  Google Scholar 

  6. Goodfellow, P., Banting, G., Levy, R., Povey, S. & McMichael, A. Somatic Cell Genet. 6, 777–787 (1980).

    Article  CAS  Google Scholar 

  7. Goodfellow, P. N. Differentiation (in the press).

  8. Report of the Nomenclature Committee Cytogenet Cell Genet. 32, 221–245 (1982).

    Article  CAS  Google Scholar 

  9. Race, R. & Sanger, R. Blood Groups in Man 6th edn (Blackwell, Oxford, 1975).

    Google Scholar 

  10. Goodfellow, P. N. & Tippett, P. Nature 289, 404–405 (1981).

    Article  ADS  CAS  Google Scholar 

  11. Ferguson-Smith, M. A., Sanger, R., Tippett, P., Aitken, D. A. & Boyd, E. Cytogenet. Cell Genet. 32, 273–274 (1982).

    Google Scholar 

  12. Tiepolo, L. et al. Hum. Genet. 54, 205–206 (1980).

    Article  CAS  Google Scholar 

  13. Mohandas, T., Shapiro, L. J., Sparkes, R. S. & Sparkes, M. C. Proc. natn. Acad. Sci. U.S.A. 76, 5779–5783 (1979).

    Article  ADS  CAS  Google Scholar 

  14. Marcus, M., Trantravali, R., Der, V. G., Miller, D. A. & Miller, O. J. Nature 262, 63–65 (1976).

    Article  ADS  CAS  Google Scholar 

  15. Daigler, S. P., Wildin, R. S. & Su, T.-S. Nature 298, 682–684 (1982).

    Article  ADS  Google Scholar 

  16. Page, D. et al. Proc. natn. Acad. Sci. U.S.A. 79, 5352–5356 (1982).

    Article  ADS  CAS  Google Scholar 

  17. Davis, R. J. med. Genet. 18, 161–197 (1981).

    Article  CAS  Google Scholar 

  18. Tanner, J. M., Prader, A., Habich, H. & Ferguson-Smith, M. A. Lancet ii, 141 (1959).

    Article  Google Scholar 

  19. Silvers, W. K., Gasser, D. C. & Eicher, E. M. Cell 28, 439–440 (1982).

    Article  CAS  Google Scholar 

  20. Goodfellow, P. N. & Andrews, P. W. Nature 295, 11–13 (1982).

    Article  ADS  CAS  Google Scholar 

  21. Shapiro, L. J., Mohandas, T., Weiss, R. & Romeo, G. Science 204, 1224–1226 (1979).

    Article  ADS  CAS  Google Scholar 

  22. Muller, C. R., Migl, B., Traupe, H. & Ropers, H. H. Hum. Genet. 54, 197–199 (1980).

    Article  CAS  Google Scholar 

  23. Darlington, C. D., Haldane, J. B. S. & Koller, P. C. Nature 133, 417–419 (1937).

    Article  ADS  Google Scholar 

  24. Burgoyne, P. S. Hum. Genet. 61, 85–90 (1982).

    Article  CAS  Google Scholar 

  25. Nabholz, M., Miggiano, V. & Bodmer, W. F. Nature 223, 358–363 (1969).

    Article  ADS  CAS  Google Scholar 

  26. Pontecorvo, G. Somatic Cell Genet. 1, 397–400 (1975).

    Article  CAS  Google Scholar 

  27. Szybalski, W., Szybalska, E. & Rayni, G. Natn. Cancer Inst. Monogr. 7, 75–89 (1962).

    Google Scholar 

  28. Kucherlapati, R. S., Baker, R. & Ruddle, F. H. Cytogenet. Cell Genet. 14, 192–193 (1975).

    Google Scholar 

  29. Harris, H. & Hopkinson, D. A. in Handbook of Enzyme Elecirophoresis in Human Genetics (North-Holland, Amsterdam, 1977).

    Google Scholar 

  30. Goodfellow, P. N. & Solomon, E. in Monoclonal Antibodies in Clinical Medicine (eds McMichael A. & Fabre, J.) 365–393 (Academic, London, 1982).

    Google Scholar 

  31. Bobrow, M. & Cross, J. Nature 251, 77–79 (1974).

    Article  ADS  CAS  Google Scholar 

  32. Seabright, M. Chromosoma 36, 204–210 (1972).

    Article  CAS  Google Scholar 

  33. Caspersson, T., Zech, L. & Johansson, C. Hereditas 67, 89–102 (1971).

    Article  Google Scholar 

  34. Williams, A. F. Eur. J. Immun. 3, 628–632 (1973).

    Article  CAS  Google Scholar 

  35. Goodfellow, P. et al. Eur. J. Immun. 12, 627–704 (1982).

    Article  Google Scholar 

  36. Kohler, G. & Milstein, C. Nature 256, 495–497 (1975).

    Article  ADS  CAS  Google Scholar 

  37. Povey, S. et al. Ann. Hum. Genet. 43, 241–248 (1980).

    Article  CAS  Google Scholar 

  38. Solomon, E. et al. Somatic Cell Genet. 2, 125–140 (1976).

    Article  CAS  Google Scholar 

  39. Hope, R. M., Goodfellow, P. N., Solomon, E & Bodmer, W. F. Cytogenet. Cell Genet. 33, 204–212 (1982).

    Article  CAS  Google Scholar 

  40. Goodfellow, P. N., Banting, G., Trowsdale, J., Chambers, S. & Solomon, E. Proc. natn. Acad. Sci. U.S.A. 79, 1190–1194 (1982).

    Article  ADS  CAS  Google Scholar 

  41. Solomon, E. et al. Cytogenet. Cell Genet. (in the press).

  42. Schweizer, D., Ambros, P. & Andrle, M. Expl Cell Res. 111, 327–332 (1978).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Imperial Cancer Research Fund, Lincoln's Inn Fields, London, WC2A 3PX, UK

    P. Goodfellow, G. Banting & D. Sheer

  2. Institute für Humangenetik and Antropologie, Albert-Ludwigs-Universität, Freiburg, FRG

    H. H. Ropers

  3. Duncan Guthrie Institute of Medical Genetics, University of Glasgow, Glasgow, G3 4SJ, UK

    A. Caine & M. A. Ferguson-Smith

  4. MRC Human Biochemical Genetics Unit, Galton Laboratories, University of London, London, NW1 2HE, UK

    S. Povey

  5. Department of Human Genetics, Hadassah Medical Centre, Ein Karem, Jerusalem, Israel

    R. Voss

Authors
  1. P. Goodfellow
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  2. G. Banting
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  3. D. Sheer
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  4. H. H. Ropers
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  5. A. Caine
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  6. M. A. Ferguson-Smith
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  7. S. Povey
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  8. R. Voss
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Goodfellow, P., Banting, G., Sheer, D. et al. Genetic evidence that a Y-linked gene in man is homologous to a gene on the X chromosome. Nature 302, 346–349 (1983). https://doi.org/10.1038/302346a0

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  • DOI: https://doi.org/10.1038/302346a0

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