Abstract
Dopamine receptors in intracerebral motor and endocrine systems1,2 have been divided into two main types, D-1 and D-2, dependent on the presence or absence of adenylate cyclase linkage3. Here we have investigated a number of dopamine agonist and antagonist drugs in man that have different actions on D-1 and D-2 receptors in animals. Motor and endocrine effects in parkinsonian subjects seem to depend on drug interaction with D-2, but not D-1, receptors. These results may have important implications for the design of anti-parkinsonian and antipsychotic agents.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ungerstedt, U. Acta physiol. scand. Suppl. 82, 1–48 (1971).
Fuxe, K. Acta physiol. scand. 58, 383–384 (1963).
Kebabian, J. W. & Calne, D. B. Nature 277, 93–96 (1979).
Thorner, M. O. Clin. Endocr. Metab. 6, 201–222 (1977).
Schorderet, M. Neurosci. Lett. 2, 187–191 (1976).
Kebabian, J. W., Petzold, G. L. & Greengard, P. Proc. natn. Acad. Sci. U.S.A. 69, 2145–2149 (1972).
Schwarcz, R., Creese, I., Coyle, J. T. & Snyder, S. H. Nature 271, 766–768 (1978).
Hyttel, J. Life Sci. 23, 551–556 (1978).
Seeman, P., Lee, T., Chau-Wong, M., Tedesco, J. & Wong, K. Proc. natn. Acad. Sci. U.S.A. 72, 4376–4380 (1975).
Price, P., Debono, A., Parkes, J. D., Marsden, C. D. & Rosenthaler, J. Br. J. clin. Pharmac. 6, 303–308 (1978).
Corrodi, H., Fuxe, K., Hokfelt, T., Lindbrink, P. & Ungerstedt, U. J. Pharm. Pharmac. 25, 409–413 (1973).
Horowski, R. & Wachter, H. Eur. J. Pharmac. 36, 373–378 (1976).
Kebabian, J. W. Life Sci. 23, 479–484 (1978).
Schmidt, M. J. & Hill, L. E. Life Sci. 20, 789–794 (1977).
Pieri, L., Keller, H. H., Burkard, W. & Daprada, M. Nature 272, 278–280 (1978).
Anden, N-E., Butcher, S. G., Corrodi, H., Fuxe, K. & Ungerstedt, U. Eur. J. Pharmac. 11, 303–314 (1970).
Miller, R. J., Horn, A. S. & Iversen, L. L. Molec. Pharmac. 10, 759–766 (1974).
Jenner, P., Elliott, P. N. C., Clow, A., Reavill, C. & Marsden, C. D. J. Pharm. Pharmac. 30, 46–48 (1978).
Shibuya, M. J. neural Transmission 44, 287–295 (1979).
Lee, T., Seeman, P., Rajput, A., Farley, I. J. & Hornykiewicz, O. Nature 273, 59–61 (1978).
Riesine, T. D. et al. Life Sci. 21, 335–344 (1977).
Cotzias, G. C., van Woert, M. H. & Schiffer, L. M. New Engl. J. Med. 276, 374–379 (1967).
Parkes, J. D. Adv. Drug Res. 13, 247–343 (1977).
Dolphin, A. C., Jenner, P., Sawaya, M. C. B., Marsden, C. D. & Testa, B. J. Pharm. Pharmac. 29, 727–736 (1977).
Marsden, C. D., Jenner, P., Parkes, J. D., Price, P. & Reavill, C. in Dopaminergic Ergot Derivatives and Motor Function (eds Fuxe, K. & Calne, D. B.) 313 (Pergamon, New York, 1979).
Costall, B. & Naylor, R. J. Eur. J. Pharmac. 33, 301–312 (1975).
Bedard, P., Parkes, J. D. & Marsden, C. D. Br. med. J. 1, 954–956 (1978).
Shoulson, I. & Chase, T. N. Neurology, Minneap. 25, 722–724 (1975).
Brown, E. M., Carull, R. J. & Aurbach, G. D. Proc. natn. Acad. Sci. U.S.A. 74, 4210–4213 (1977).
McAfee, D. A. & Greengard, P. Science 178, 310–312 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schachter, M., Bédard, P., Debono, A. et al. The role of D-1 and D-2 receptors. Nature 286, 157–159 (1980). https://doi.org/10.1038/286157a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/286157a0
- Springer Nature Limited
This article is cited by
-
A history of dopamine agonists. From the physiology and pharmacology of dopamine to therapies for prolactinomas and Parkinson’s disease – a subjective view
Journal of Neural Transmission (2007)
-
Turning behavior in rats with unilateral lesion of the subthalamic nucleus: synergism between D1 and D2 receptors
Journal of Neural Transmission (1995)
-
Binding of (+)PHNO and other D2-dopamine agonists to D1-dopamine receptors labelled by [3H]SCH 23390
Journal of Neural Transmission (1987)
-
Effect of terguride on prolactin levels in normal, puerperal and hyperprolactinaemic women
European Journal of Clinical Pharmacology (1986)