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A UGA termination suppression tRNATrp active in rabbit reticulocytes

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Abstract

A tRNATrp was purified from rabbit reticulocytes which suppresses the UGA termination codon of β-haemoglobin mRNA. Evidence is presented that the β-haemoglobin readthrough protein is found in reticulocyte translations and intact cells. Some natural readthrough proteins perform essential functions; they are synthesised through suppression of UGA or UAG but not UAA termination codons.

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Authors and Affiliations

  1. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139

    Alfred I. Geller & Alexander Rich

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  1. Alfred I. Geller
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  2. Alexander Rich
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Geller, A., Rich, A. A UGA termination suppression tRNATrp active in rabbit reticulocytes. Nature 283, 41–46 (1980). https://doi.org/10.1038/283041a0

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  • DOI: https://doi.org/10.1038/283041a0

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