Abstract
Cell-surface differentiation antigens which are associated with particular lymphocyte subsets are likely to be molecules which mediate specific functions of the cells which display them. One way to investigate this hypothesis is to see whether antibodies directed against such antigens will inhibit functional systems. This approach can be attempted with confidence if monoclonal antibodies are used, as these react with one antigenic determinant only and can be used in purified form. In this report we show that a monoclonal antibody which is specific for a subset of rat T lymphocytes inhibits the mixed lymphocyte response (MLR). The antibody acts on the responder cells without killing them.
Similar content being viewed by others
References
Williams, A. F., Galfre, G. & Milstein, C. Cell, 12, 663–673 (1977).
White, R. A. H., Mason, D. W., Williams, A. F., Galfre, G. & Milstein, C. J. exp. Med. 148, 664–673 (1978).
Antczak, D. F., Brown, D. & Howard, J. C. Cell. Immun. 43, 304–316 (1979).
Sunderland, C. A., McMaster, W. R. & Williams, A. F. Eur. J. Immun. 9, 155–159 (1978).
Acton, R. T., Morris, R. J. & Williams, A. F. Eur. J. Immun. 4, 598–602 (1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Webb, M., Mason, D. & Williams, A. Inhibition of mixed lymphocyte response by monoclonal antibody specific for a rat T lymphocyte subset. Nature 282, 841–843 (1979). https://doi.org/10.1038/282841a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/282841a0
- Springer Nature Limited
This article is cited by
-
Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene
Nature (1987)
-
Characterization of inflammatory cells in autoimmune tubulointerstitial nephritis in rats
Kidney International (1983)
-
The T lymphocyte antigen receptor—paradigm lost
Nature (1982)