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Molecular structure of a left-handed double helical DNA fragment at atomic resolution

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Abstract

The DNA fragment d(CpGpCpGpCpG) crystallises as a left-handed double helical molecule with Watson–Crick base pairs and an antiparallel organisation of the sugar phosphate chains. The helix has two nucleotides in the asymmetric unit and contains twelve base pairs per turn. It differs significantly from right-handed B-DNA.

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Authors and Affiliations

  1. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139

    Andrew H.-J. Wang, Gary J. Quigley, Francis J. Kolpak, James L. Crawford & Alexander Rich

  2. Department of Organic Chemistry, Gorlaeus Laboratories, University of Leiden, The Netherlands

    Jacques H. van Boom & Gijs van der Marel

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  1. Andrew H.-J. Wang
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  2. Gary J. Quigley
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  3. Francis J. Kolpak
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  4. James L. Crawford
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  5. Jacques H. van Boom
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  6. Gijs van der Marel
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  7. Alexander Rich
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Wang, AJ., Quigley, G., Kolpak, F. et al. Molecular structure of a left-handed double helical DNA fragment at atomic resolution. Nature 282, 680–686 (1979). https://doi.org/10.1038/282680a0

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