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Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells

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Abstract

Until now the inierfer on-mediated 2′–5′ adenine oligonucleotide inhibitors (2–5A) of cell-free protein synthesis have not been detected in intact cells. Here we report their natural occurrence in interferon-treated, EMC virus-infected mouse L cells in amounts consistent with the idea that they play a part in the inhibition of virus growth.

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Author notes

  1. R. R. Golgher

    Present address: Departmento de Microbiologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

Authors and Affiliations

  1. National Institute for Medical Research, Mill Hill, London, NW7, UK

    B. R. G. Williams, R. R. Golgher, R. E. Brown, C. S. Gilbert & I. M. Kerr

Authors
  1. B. R. G. Williams
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  2. R. R. Golgher
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  3. R. E. Brown
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  4. C. S. Gilbert
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  5. I. M. Kerr
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Williams, B., Golgher, R., Brown, R. et al. Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells. Nature 282, 582–586 (1979). https://doi.org/10.1038/282582a0

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