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The heavy chain of human histocompatibility antigen HLA-B7 contains an immunoglobulin-like region

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Abstract

The 88-residue fragment (ac-2) containing the second disulphide loop from HLA-B7 heavy chain is shown to have statistically significant homology with Ig constant domains, including both matches at invariant positions and conservative substitutions of structurally important residues. Thus, both the light chain (β2m) and a segment of the heavy chain of HLA antigens may be structurally and evolutionarily related to immunoglobulins.

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Authors and Affiliations

  1. Harvard University, The Biological Laboratories, Cambridge, Massachusetts, 02138

    Harry T. Orr, Doron Lancet, Richard J. Robb, José A. Lopez de Castro & Jack L. Strominger

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  1. Harry T. Orr
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  2. Doron Lancet
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  3. Richard J. Robb
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  4. José A. Lopez de Castro
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  5. Jack L. Strominger
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Orr, H., Lancet, D., Robb, R. et al. The heavy chain of human histocompatibility antigen HLA-B7 contains an immunoglobulin-like region. Nature 282, 266–270 (1979). https://doi.org/10.1038/282266a0

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  • DOI: https://doi.org/10.1038/282266a0

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