Abstract
In higher organisms the rate of recombination between genetic loci is presumably responsive to selective pressure. Recently, selective pressures1 and mutational events2 that influence recombination have been reviewed. Mutational sites and chromosomal rearrangements that enhance or suppress recombination frequency in specific regions are known, but general mechanisms that enhance recombination have not yet been discovered. We describe here the isolation and characterisation of a strain of the hermaphroditic nematode, Caenorhabditis elegans, that has a recombination frequency at least threefold higher than that found in the wild type3,4. In this strain, rec-1, the number of reciprocal recombination events between linked loci is increased. This is true for all pairs of linked loci studied so far. The high recombination strain behaves as if it carries a classical, recessive mutation, although a second mutation exists which can alter the recessive behaviour of rec-1.
Similar content being viewed by others
References
Maynard-Smith, J. The Evolution of Sex (Cambridge University Press, 1978).
Catcheside, D. G. The Genetics of Recombination (University Park Press, Baltimore, 1977).
Brenner, S. Genetics 77, 71–94 (1974).
Rose, A. M. & Baillie, D. L. Genetics (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rose, A., Baillie, D. A mutation in Caenorhabditis elegans that increases recombination frequency more than threefold. Nature 281, 599–600 (1979). https://doi.org/10.1038/281599a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/281599a0
- Springer Nature Limited
This article is cited by
-
Variability of recombination frequencies in the Iowa Stiff Stalk Synthetic (Zea mays L.)
Theoretical and Applied Genetics (1993)
-
Tcl transposition and mutator activity in a Bristol strain of Caenorhabditis elegans
Molecular and General Genetics MGG (1990)
-
Meiotic pairing behavior of two free duplications of linkage group I in Caenorhabditis elegans
Molecular and General Genetics MGG (1984)
-
Genetic manipulation in plant breeding: somatic versus generative
Theoretical and Applied Genetics (1983)