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Comparison of cloned rabbit and mouse β-globin genes showing strong evolutionary divergence of two homologous pairs of introns

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Abstract

Cloned β-globin genes of both mouse and rabbit each contain a large and a small intervening sequence (intron) of about equal length at precisely the same positions relative to the coding sequence. The homologous introns show some sequence similarity, particularly at the junctions with the coding sequence. They most probably arose from a common ancestral sequence and diverged substantially during evolution.

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Authors and Affiliations

  1. Institut für Molekularbiologie I, Universität Zürich, 8093, Zürich, Switzerland

    Johan van den Berg, Albert van Ooyen, Ned Mantei, Anton Schamböck & Charles Weissmann

  2. Section for Medical Enzymology and Molecular Biology, Laboratory of Biochemistry, University of Amsterdam, Amsterdam, The Netherlands

    Gerard Grosveld & Richard A. Flavell

Authors
  1. Johan van den Berg
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  2. Albert van Ooyen
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  3. Ned Mantei
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  4. Anton Schamböck
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  5. Gerard Grosveld
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  6. Richard A. Flavell
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  7. Charles Weissmann
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van den Berg, J., van Ooyen, A., Mantei, N. et al. Comparison of cloned rabbit and mouse β-globin genes showing strong evolutionary divergence of two homologous pairs of introns. Nature 276, 37–44 (1978). https://doi.org/10.1038/276037a0

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  • DOI: https://doi.org/10.1038/276037a0

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