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Evolution of α- and β-Globin genes and their regulatory systems in light of the hypothesis of domain organization of the genome

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Abstract

The α- and β-globin gene domains are a traditional model for study of the domain organization of the eucaryotic genome because these genes encode hemoglobin, a physiologically important protein. The α-globin and β-globin gene domains are organized in completely different ways, while the expression of globin genes is tightly coordinated, which makes it extremely interesting to study the origin of these genes and the evolution of their regulatory systems. In this review, the organization of the α- and β-globin gene domains and their genomic environment in different taxonomic groups are comparatively analyzed. A new hypothesis of possible evolutionary pathways for segregated α- and β-globin gene domains of warm-blooded animals is proposed.

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Abbreviations

LCR:

locus control region

MRE:

major regulatory element

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Authors and Affiliations

  1. Institute of Gene Biology, Russian Academy of Sciences, ul. Vavilova 34/5, 119334, Moscow, Russia

    O. V. Iarovaia, E. S. Ioudinkova, N. V. Petrova, K. V. Dolgushin & S. V. Razin

  2. Joint Russian-French Laboratory LIA1066, Moscow, Paris, Russia, France

    O. V. Iarovaia, E. S. Ioudinkova, N. V. Petrova, K. V. Dolgushin, Y. S. Vassetzky & S. V. Razin

  3. Biological Faculty, Lomonosov Moscow State University, 119991, Moscow, Russia

    A. V. Kovina, A. V. Nefedochkina & S. V. Razin

  4. Institute Gustave Roussy, 39 rue Camille-Desmoulins, 94805, Villejuif, France

    Y. S. Vassetzky

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Original Russian Text © O. V. Iarovaia, E. S. Ioudinkova, N. V. Petrova, K. V. Dolgushin, A. V. Kovina, A. V. Nefedochkina, Y. S. Vassetzky, S. V. Razin, 2014, published in Biokhimiya, 2014, Vol. 79, No. 11, pp. 1405–1416.

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Iarovaia, O.V., Ioudinkova, E.S., Petrova, N.V. et al. Evolution of α- and β-Globin genes and their regulatory systems in light of the hypothesis of domain organization of the genome. Biochemistry Moscow 79, 1141–1150 (2014). https://doi.org/10.1134/S0006297914110017

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