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Nerve growth factor-induced increase in electrical excitability and acetylcholine sensitivity of a rat pheochromocytoma cell line

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Abstract

A cloned line of rat pheochromocytoma cells (PC12) which responds to nerve growth factor (NGF) by cessation of division and extension of neurone-like processes, is shown to develop electrical excitability and greatly increased acetylcholine sensitivity in the presence of NGF. This implies that NGF influences the physiological differentiation of certain neural crest derivatives.

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Authors and Affiliations

  1. Department of Neurology and Pathology, Harvard Medical School and Beth Israel Hospital, Boston, Massachusetts, 02215

    Marc A. Dichter & Arthur S. Tischler

  2. Department of Neuropathology, Harvard Medical School and Department of Neuroscience, Children's Hospital Medical Center, Boston, Massachusetts, 02215

    Lloyd A. Greene

Authors
  1. Marc A. Dichter
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  2. Arthur S. Tischler
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  3. Lloyd A. Greene
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Dichter, M., Tischler, A. & Greene, L. Nerve growth factor-induced increase in electrical excitability and acetylcholine sensitivity of a rat pheochromocytoma cell line. Nature 268, 501–504 (1977). https://doi.org/10.1038/268501a0

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  • DOI: https://doi.org/10.1038/268501a0

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