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Endorphin from pituitary inhibits cyclic AMP formation in homogenates of neuroblastoma × glioma hybrid cells

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Abstract

OPIATES inhibit basal and prostaglandin E1-stimulated formation of cyclic AMP by homogenates of cultured neuroblastoma × glioma hybrid cells1,2. The opiate inhibition is stereospecific and is blocked by the specific opiate antagonist naloxone. Thus, interaction of an opiate agonist with its receptor inhibits adenylate cyclase activity.

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Authors and Affiliations

  1. Addiction Research Foundation, Palo Alto, California, 94304

    AVRAM GOLDSTEIN & BRIAN M. COX

  2. National Institute of Mental Health, and National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland, 20014

    WERNER A. KLEE & MARSHALL NIRENBERG

Authors
  1. AVRAM GOLDSTEIN
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  2. BRIAN M. COX
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  3. WERNER A. KLEE
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  4. MARSHALL NIRENBERG
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GOLDSTEIN, A., COX, B., KLEE, W. et al. Endorphin from pituitary inhibits cyclic AMP formation in homogenates of neuroblastoma × glioma hybrid cells. Nature 265, 362–363 (1977). https://doi.org/10.1038/265362a0

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  • DOI: https://doi.org/10.1038/265362a0

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