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Neuropeptide cycloprolylglycine increases the levels of brain-derived neurotrophic factor in neuronal cells

  • Biochemistry, Biophysics, and Molecular Biology
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Abstract

It was shown for the first time that the endogenous cyclic dipeptide cycloprolylglycine (CPG) at concentrations of 10–7 and 10–3 M and piracetam at a concentration of 10–3 M increased the content of brainderived neurotrophic factor (BDNF) in the culture of neuronal cells in normal state and under conditions of glutamate and 6-oxydopamine neurotoxicity. This may indicate the possible involvement of BDNF in the mechanism of action of neuropeptide CPG and piracetam.

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Authors and Affiliations

  1. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, ul. Baltiiskaya 8, Moscow, 125315, Russia

    T. A. Gudasheva, K. N. Koliasnikova, T. A. Antipova & S. B. Seredenin

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  1. T. A. Gudasheva
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  2. K. N. Koliasnikova
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  3. T. A. Antipova
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  4. S. B. Seredenin
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Corresponding author

Correspondence to T. A. Gudasheva.

Additional information

Original Russian Text © T.A. Gudasheva, K.N. Koliasnikova, T.A. Antipova, S.B. Seredenin, 2016, published in Doklady Akademii Nauk, 2016, Vol. 469, No. 4, pp. 492–495.

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Gudasheva, T.A., Koliasnikova, K.N., Antipova, T.A. et al. Neuropeptide cycloprolylglycine increases the levels of brain-derived neurotrophic factor in neuronal cells. Dokl Biochem Biophys 469, 273–276 (2016). https://doi.org/10.1134/S1607672916040104

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  • DOI: https://doi.org/10.1134/S1607672916040104

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