Skip to main content
SpringerLink
Log in

Polymers for the sustained release of proteins and other macromolecules

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

An Erratum to this article was published on 18 November 1976

Abstract

SINCE the first demonstration that silicone rubber1 could be used as an implantable carrier for sustained delivery of low molecular weight compounds in animal tissues, various drug delivery systems have been developed. But except for the reports of Davis2,3 and Girnbrone et al.4, there has been little success in the development of slow release agents for large molecular weight compounds. Furthermore, the polymers used in those studies, polyvinylpyrrolidone and polyacrylamide, are often inflammatory in animal tissues and usually permit only brief periods of sustained release. We now present a simple method for incorporating various proteins and other macromolecules into non-inflammatory polymers. Sustained release of biochemically active macromolecules has been demonstrated for periods exceeding 100 d.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Folkman, J., and Long, D. M., J. surg. Res., 4, 139–142 (1964).

    Article  CAS  Google Scholar 

  2. Davis, B. K., Experientia, 28, 348 (1972).

    Article  CAS  Google Scholar 

  3. Davis, B. K., Proc. natn. Acad. Sci. U.S.A., 71, 3120–3123 (1974).

    Article  ADS  CAS  Google Scholar 

  4. Gimbrone, M. A., Jr, Cotran, R. S., Leapman, S. B., and Folkman, J., J. natn. Cancer Inst., 42, 314–427 (1974).

    Google Scholar 

  5. Fromer, C. H., and Klintworth, G. K., Am. J. Path., 79, 537–554 (1975).

    CAS  PubMed  Google Scholar 

  6. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem. 193, 265–275 (1951).

    CAS  Google Scholar 

  7. Bittner, T., and Muir, H., Analyt. Biochem., 4, 330–334 (1962).

    Article  Google Scholar 

  8. Furano, A. V., Analyt. Biochem., 43, 639–640 (1972).

    Article  Google Scholar 

  9. Soeldner, J. S., and Salone, D., Diabetes, 14, 771 (1965).

    Article  CAS  Google Scholar 

  10. Carlsson, L., and Karlsson, B., Experientia, 28, 990–991 (1972).

    Article  CAS  Google Scholar 

  11. Schill, W. R., and Schumacher, G. F. B., Analyt. Biochem., 46, 502–533 (1972).

    Article  CAS  Google Scholar 

  12. Schumacher, G. F. B., and Schill, W. R., Analyt. Biochem., 48, 9–26 (1972).

    Article  CAS  Google Scholar 

  13. Folkman, J., Cancer Res., 34, 2109–2113 (1974).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, Children's Hospital Medical Center and Harvard Medical School, Boston, Massachusetts, 02115

    ROBERT LANGER & JUDAH FOLKMAN

Authors
  1. ROBERT LANGER
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. JUDAH FOLKMAN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

LANGER, R., FOLKMAN, J. Polymers for the sustained release of proteins and other macromolecules. Nature 263, 797–800 (1976). https://doi.org/10.1038/263797a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/263797a0

  • Springer Nature Limited

This article is cited by

Search

Navigation