Abstract
THERE is evidence which suggests that the release of gonadotropin-releasing hormone (GRH) is modulated by dopaminergic neurones1–3. Dopamine receptors seem to be hyper-responsive in Huntington's chorea4,5, and consequently the synthesis and secretion of GRH may be altered in this condition. For this reason we have compared the concentration of immunoreactive GRH in hypothalamic tissues taken postmortem from choreic and non-choreic (‘control’) subjects. The distribution of GRH in the human brain, and changes in concentration which occur with age have also been examined.
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BIRD, E., CHIAPPA, S. & FINK, G. Brain immunoreactive gonadotropin-releasing hormone in Huntington's chorea and in non-choreic subjects. Nature 260, 536–538 (1976). https://doi.org/10.1038/260536a0
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DOI: https://doi.org/10.1038/260536a0
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