Abstract
There is an imposing array of evidence which indicates that the anterior pituitary is a gland under neural control but lacking a secretomotor innervation. Instead, there is the hypophyseal portal system of veins which provides a specialized vascular link between hypothalamus and anterior pituitary. The first concept was that hypothalamic impulses for the discharge of trophic hormones might be some general synaptic mediators, released from nerve endings into capillary loops of the median eminence and then transported via the portal circulation into the sinusoids of the anterior lobe (Hinsey, 1937; Green and Harris, 1949). Stalk portal vessels and neural lobe portal vessels join the sinusoids in the pars distalis (for ref. see Porter, Hines, Smith, Repass and Smith, 1967). Although the interest has been focused on the stalk portal vessels (Green and Harris, 1949), the posterior lobe hormones were early considered as possible mediators for the release of the tropic hormones. This hypothesis was based partially on certain stimulating effects of the posterior lobe hormones on the adenohypophysis (Martini, 1954; McCann and Dhariwal, 1966).
This study was supported by the Ford Foundation and Public Health Service Grant AM 10073-04.
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References
Antunes-Rodrigues, J., Dhariwal, A. P. S., McCann, S. M.: Effect of purified luteinizing hormone-releasing factor (LH-RF) on plasma LH activity at various stages of the estrous cycle of the rat. Proc. Soc. exp. Biol. (N.Y.) 122, 1001–1004 (1966).
Everett, J. W.: Neuroendocrine aspects of mammalian reproduction. Ann. Rev. Physiol. 31, 383–416 (1969).
Fuxe, K., Hökfelt, T.: The influence of central catecholamine neurons on the hormone secretion from the anterior and posterior pituitary. In: Proc. 4th Intern. Symp. on Neurosecretion, edit, by F. Stutinsky, p. 165–177. Berlin-Heidelberg-New York: Springer 1967.
Fuxe, K., Hökfelt, T., Nilsson, O.: Activity changes in the tuberoinfundibular dopamine neurons of the rat during various states of the reproductive cycle. Life Sci. 6, 2057–2061 (1967).
Gaddum, F. H.: Simplified mathematics for bioassays. J. Pharm. Pharmacol. 5, 345–358 (1953).
Green, J. D., Harris, G. W.: Observation of the hypophysioportal vessels of the living rat. J. Physiol. (Lond.) 108, 359–361 (1949).
Hillarp, N.-Ä., Fuxe, K., Dahlström, A.: Demonstration and mapping of central neurons containing dopamine, noradrenaline and 5-hydroxytryptamine and their reactions to psychopharmaca. Pharmacol. Rev. 18, 727–741 (1966).
Hinsey, J. C.: The relation of the nervous system to ovulation and other phenomena of the female reproductive tract. Cold Spr. Harb. Symp. quant. Biol. 5, 269–279 (1937).
Kamberi, I., McCann, S. M.: Effect of biogenic amines and other substances on the release of follicle stimulating hormone by pituitaries incubated in vitro. J. Reprod. Fértil. 18, 153 (1969).
Kamberi, I., Schneider, H. P. G., McCann, S. M.: Action of dopamine to induce release of FSH-releasing factor (FRF) from hypothalamic tissue in vitro. Endocrinology 86, 278 (1970).
Kordon, C.: Effects of selective experimental changes in regional hypothalamic monoamine levels on superovulation in the immature rat. Neuroendocrinology 4, 129–138 (1969).
Lippmann, W., Leonardi, R., Ball, J., Coppola, J. A.: Relationship between hypothalamic catecholamines and gonadotrophin synthesis in rats. J. Pharmacol. exp. Ther. 156, 258–266 (1967).
Martini, L., Fraschini, F., Motta, M.: Neural control of anterior pituitary functions. Recent Progr. Hormone Res. 24, 439–496 (1968).
McCann, S. M., Porter, J. C.: Hypothalamic pituitary stimulating and inhibiting hormones. Physiol. Rev. 49, 240–284 (1969).
McCann, S. M., Dhariwal, A. P. S.: Hypothalamic releasing factors and the neurovascular link between brain and anterior pituitary, p. 261–296. In: Neuroendocrinology, edit, by L. Martiniand W. F. Ganong. New York: Academic Press 1966.
McClintock, J. A., Schwartz, N. B.: Changes in pituitary and plasma follicle stimulating hormone concentrations during the rat estrous cycle. Endocrinology 83, 433–441 (1968).
Meyerson, B. J., Sawyer, C. H.: Monoamines and ovulation in the rat. Endocrinology 83, 170–176 (1968).
Nallar, R., McCann, S. M.: LH-releasing activity in plasma of hypophysectomized rats. Endocrinology 76, 272–294 (1965).
Niswender, G. D., Midgley, A. R., Jr., Monroe, S. E., Reichert, L. E., Jr.: Radioimmunoassay for rat luteinizing hormone with antiovine LH serum and ovine LH-131I. Proc. Soc. exp. Biol. (N.Y.) 128, 807–811 (1968).
Parlow, A. F.: Bio-assay of pituitary luteinizing hormone by depletion of ovarian ascorbic acid. In: A. Albert, Human pituitary gonadotropins, p. 300–310. Springfield, Illinois: Ch. C. Thomas 1961.
Parlow, A. F., Daane, T. A., Schally, A. V.: Quantitative, differential measurement of rat serum FSH, LH and hypothalamic FSH-RH and LH-RH with specific radioimmunoassays. 51st Annual Meeting Amer. Endocr. Soc. 106, 83 (1969).
Parlow, A. F., Reichert, L. E., Jr.: Species differences in follicle stimulating hormone as revealed by the slope in the Steelman-Pohley assay. Endocrinology 73, 740–743 (1963).
Porter, J. C., Hines, M. F. M., Smith, K. R., Repass, R. L., Smith, A. J. K.: Quantitative evaluation of local blood flow of the adenohypophysis in rats. Endocrinology 80, 583–598 (1967).
Ramirez, V. D., McCann, S. M.: A new sensitive test for LH-releasing activity: the ovariecto-mized, estrogen progesterone-blocking rat. Endocrinology 73, 193–198 (1963).
Schneider, H. P. G., McCann, S. M.: Possible role of dopamine as transmitter to promote discharge of LH-releasing factor. Endocrinology 85, 121–132 (1969a).
Schneider, H. P. G., McCann, S. M.: Intraventricular mono- or indolamines and LH release in the rat. Physiologist (vol. 12, no. 3 1969b).
Schneider, H. P. G., McCann, S. M.: Feedback of estradiol upon median eminence and anterior pituitary in vitro. 51st Annual Meeting Amer. Endocr. Soc. 108, 84 (1969c).
Schneider, H. P. G., McCann, S. M.: Effect of dopamine on release of LH-releasing factor by stalk-median eminence tissue in vitro. Fed. Proc. 28, 381 (1969d).
Steelman, S. L., Pohley, F. M.: Assay of the follicle stimulating hormone based on the augmentation with human chorionic gonadotropin. Endocrinology 53, 604–616 (1953).
Swerdloff, R. S., Odell, W. D.: Some aspects of the control of secretion in LH and FSH in humans. In: Gonadotropins, edit. by E. Rosemberg, p. 155–162. Los Altos, Calif.: Geron-X, Inc. 1968.
White, W. F., Cohen, A. I., Rippel, R. H., Storey, J. C., Schally, A. V.: Some hypothalamic polyamines that deplete pituitary follicle stimulating hormone. Endocrinology 82, 742–752 (1968).
Yeh, B. K., McNay, J. L., Goldberg, L. T.: Attenuation of dopamine renal and mesenteric vasodilation by haloperidol: evidence for a specific dopamine receptor. J. Pharmacol. exp. Ther. (in press).
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Schneider, H.P.G., McCann, S.M. (1970). Dopaminergic Pathways and Gonadotropin Releasing Factors. In: Bargmann, W., Scharrer, B. (eds) Aspects of Neuroendocrinology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46207-8_19
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