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Subthreshold membrane currents in slowly adapting stretch receptor neurone of lobster

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Abstract

IN the slowly adapting stretch receptor neurone of lobster, application of tetrodotoxin (TTX) causes a simultaneous hyperpolarisation and decrease in input resistance1. These effects have been attributed to a possible increase in potassium conductance. They could, however, be explained by elimination of a subthreshold steady-state sodium conductance which, in this case, might underlie the cell's repetitive mode of firing2. To examine this possibility, we made a voltage clamp study of the subthreshold steady-state membrane currents of the slowly adapting stretch receptor neurone of lobster. The results indicate the existence of a subthreshold steady-state Na current which to a large extent seems to be balanced by a leak type current.

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References

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Authors and Affiliations

  1. Department of Physiology and Biophysics, University of Lund, Lund, Sweden

    W. GRAMPP & L. SJÖLIN

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  1. W. GRAMPP
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  2. L. SJÖLIN
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GRAMPP, W., SJÖLIN, L. Subthreshold membrane currents in slowly adapting stretch receptor neurone of lobster. Nature 257, 697–698 (1975). https://doi.org/10.1038/257697a0

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  • DOI: https://doi.org/10.1038/257697a0

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