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Permeability of solutes through biological membranes measured by a desorption technique

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Abstract

THE influence of molecular structure of a solute on its permeation through biological membranes has been evaluated by various methods1–4. For permeation of a solute across a membrane of thickness, h, the permeability coefficient, P, can be expressed in terms of the membrane–solution partition coefficient (Km) and the diffusion coefficient in the membrane (D): P=KmD/h (1)

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Authors and Affiliations

  1. Department of Pharmacy, University of Sydney, New South Wales, 2006, Australia

    M. S. ROBERTS, E. J. TRIGGS & R. A. ANDERSON

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  1. M. S. ROBERTS
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  2. E. J. TRIGGS
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  3. R. A. ANDERSON
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ROBERTS, M., TRIGGS, E. & ANDERSON, R. Permeability of solutes through biological membranes measured by a desorption technique. Nature 257, 225–227 (1975). https://doi.org/10.1038/257225a0

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