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Comparative growth of bovine lymphosarcoma cells and lymphoid cells infected with Theileria parva in athymic (nude) mice

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Abstract

TUMOUR-LIKE growth of bovine lymphoid cells infected with Theileria parva has been observed in whole-body irradiated athymic (nude) mice using cells isolated direct from fatal cases of East Coast fever1, and also using lymphoid cells infected with T. parva, maintained as lines in culture2. Here we compare the growth, in irradiated athymic mice, of this latter cell type with that of similar bovine transformed lymphoid cells of known neoplastic origin. The results contrast with those recorded in the natural conditions in cattle, since cells infected with T. parva grew malignantly in mice whereas bovine lymphosarcoma cells formed localised non-invasive tumours.

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Author notes

  1. A. D. IRVIN

    Present address: ARC Institute for Research on Animal Diseases, Compton, Berkshire, UK

  2. D. A. STAGG

    Present address: Central Veterinary Laboratory, Weybridge, Surrey, UK

  3. C. G. D. BROWN and G. K. KANHAI: FAO staff members.

  4. A. D. IRVIN: Formerly on ODM Secondment, Project R2845.

  5. D. A. STAGG: Formerly on ODM Secondment, Project R2845.

Authors and Affiliations

  1. UNDP/FAO Tick-borne Diseases Project, East African Veterinary Research Organization, Muguga, PO Box 32, Kikuyu, Kenya

    A. D. IRVIN, C. G. D. BROWN, G. K. KANHAI & D. A. STAGG

Authors
  1. A. D. IRVIN
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  2. C. G. D. BROWN
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  3. G. K. KANHAI
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  4. D. A. STAGG
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IRVIN, A., BROWN, C., KANHAI, G. et al. Comparative growth of bovine lymphosarcoma cells and lymphoid cells infected with Theileria parva in athymic (nude) mice. Nature 255, 713–714 (1975). https://doi.org/10.1038/255713a0

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  • DOI: https://doi.org/10.1038/255713a0

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