Skip to main content
SpringerLink
Log in

Tumour-associated transplantation antigens of chemically induced sarcomata cross reacting with allogeneic histocompatibility antigens

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

INDIVIDUAL tumour-associated transplantation antigens (TATA) of chemically induced tumours and histocompatibility antigens (HA) share the ability of inducing transplantation immunity, and have other properties in common, such as the high degree of polymorphism1–3 and a similar cell surface behaviour4. A reciprocal relationship between the quantitative expression of TATA and H-2 antigens has been observed5–6, suggesting the existence of common mechanisms either in their synthesis or in the control of their phenotypic expression. Such indirect similarity prompted us to study the existence of cross reactions between TATA and HA. We therefore determined whether 3-methylcholanthrene (MCA)-induced sarcomata possess TATA-containing allogeneic histocompatibility determinants. Here we report data from two BALB/c fibrosarcomas, ST-5 and B-2.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Basombrio, M. A., Cancer Res., 30, 2458–2462 (1970).

    CAS  PubMed  Google Scholar 

  2. Demant, P., Transplant. Rev., 15, 162–200 (1973).

    CAS  PubMed  Google Scholar 

  3. Graff, R. J., and Bailey, D. W., Transplant. Rev., 15, 26–49 (1973).

    CAS  PubMed  Google Scholar 

  4. Yefenof, E., and Klein, G., Expl Cell. Res., 88, 217–224 (1974).

    Article  CAS  Google Scholar 

  5. Haywood, G. R., and McKhann, C. F., J. exp. Med., 133, 1171–1187 (1971).

    Article  CAS  Google Scholar 

  6. Tsakraklides, E., Smith, C., Hersey, J. H., and Good, R. A., J. natn. Cancer Inst., 52, 1499–1504 (1974).

    Article  CAS  Google Scholar 

  7. Parmiani, G., Carbone, G., and Lembo, R., Cancer Res., 33, 750–754 (1973).

    CAS  PubMed  Google Scholar 

  8. Fenyo, E. M., Wiener, F., Klein, G., and Harris, H., J. natn. Cancer Inst., 51, 1865–1875 (1973).

    Article  CAS  Google Scholar 

  9. Oth, D., and Barra, Y., C.r. hebd. Séanc. Acad. Sci., Paris, 278, 177–180 (1974).

    CAS  Google Scholar 

  10. Snell, G. D., Immunogenetics, 1, 1–3 (1974).

    Article  Google Scholar 

  11. Prehn, R. T., J. natn. Cancer Inst., 45, 1039–1045 (1970).

    CAS  Google Scholar 

  12. Bodmer, W. F., Transplant. Proc., 5, 1471–1475 (1973).

    CAS  PubMed  Google Scholar 

  13. Martin, W. J., Esber, E., Cotton, W. G., and Rice, J. M., Br. J. Cancer, 28, suppl. 1, 48–61 (1973).

    Google Scholar 

  14. Colnaghi, M. I., and Della Porta, G., J. natn. Cancer Inst., 50, 173–180 (1973).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Experimental Oncology A, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133, Milano, Italy

    GIOVANNI INVERNIZZI & GIORGIO PARMIANI

Authors
  1. GIOVANNI INVERNIZZI
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. GIORGIO PARMIANI
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

INVERNIZZI, G., PARMIANI, G. Tumour-associated transplantation antigens of chemically induced sarcomata cross reacting with allogeneic histocompatibility antigens. Nature 254, 713–714 (1975). https://doi.org/10.1038/254713a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/254713a0

  • Springer Nature Limited

This article is cited by

Search

Navigation