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Lipopolysaccharide induces C-type virus in short term cultures of BALB/c spleen cells

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Abstract

IN certain strains of mice, such as AKR, C-type viruses occur throughout life and can readily be detected by infectivity assays1,2. In other seemingly virus-free strains, C-type viruses can be activated in vivo by X irradiation3,4, chemical carcinogens5, graft-versus-host reactions6 and in vitro by long term cultivation7, by X rays8, halogenated pyrimidine analogues9,10 and mixed lymphocyte reactions6. We report here that lipopolysaccharide, a B-cell mitogen18, induces C-type virus in short term cultures of BALB/c spleen cells.

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Authors and Affiliations

  1. Friedrich Miescher-Institut, Basel, Switzerland

    CHRISTOPH MORONI

  2. Biological Research Laboratories, Pharmaceutical Division, CIBA-GEIGY Limited, Basel, Switzerland

    GEBHARD SCHUMANN

Authors
  1. CHRISTOPH MORONI
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  2. GEBHARD SCHUMANN
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MORONI, C., SCHUMANN, G. Lipopolysaccharide induces C-type virus in short term cultures of BALB/c spleen cells. Nature 254, 60–61 (1975). https://doi.org/10.1038/254060a0

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  • DOI: https://doi.org/10.1038/254060a0

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